Musculoskeletal manifestations in inflammatory bowel disease

Carlo Salvarani, Giovanni Fornaciari, Marina Beltrami, Pier Luigi MacChioni

Research output: Contribution to journalArticlepeer-review


Musculoskeletal manifestations are the most common extra-intestinal complication of inflammatory bowel disease (IBD). They are part of the clinical spectrum of spondylarthropathies and include different articular manifestations. In addition to axial symptoms, peripheral findings such as seronegative oligoarthritis, dactylitis, and enthesopathy commonly occur, sometimes representing the only manifestation. Wide ranges of prevalence have been reported, depending on the criteria used to define spondyloarthropathy and on the selection of patients. In an inceptional cohort of newly diagnosed IBD patients, we observed musculoskeletal manifestations in 30.7% of the patients. The clinician should, therefore, carefully evaluate any rheumatological findings in order to provide an accurate and early diagnosis, and to establish an adequate therapy. In this article, epidemiological, clinical, and diagnostic aspects are discussed. Furthermore, the contribution of intestinal bacteria and immunogenetic factors to the pathogenesis of arthritis is briefly reviewed. Finally, we summarize the available therapeutic options. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalEuropean Journal of Internal Medicine
Issue number4
Publication statusPublished - Aug 2000


  • ESSG criteria
  • Extraintestinal manifestations
  • Inflammatory bowel disease
  • Spondylarthropathy

ASJC Scopus subject areas

  • Medicine(all)
  • Internal Medicine


Dive into the research topics of 'Musculoskeletal manifestations in inflammatory bowel disease'. Together they form a unique fingerprint.

Cite this