Mutagenic Activity of Some Platinum Complexes: Chemical Properties and Biological Activity+

M. Coluccia, M. Correale, D. Giordano, M. A. Marigglo, F. P. Fanizzi, G. Natile, L. Maresca, M. Tamaro

Research output: Contribution to journalArticle

Abstract

In order to find correlations between chemical reactivity and biological activity, we have started an investigation on the mutagenic activity of different platinum-chloro-amine complexes towards different strains of Salmonella Typhimurium. The first class of compounds examined includes complexes of general formula cis-[PtCI2(amine)(L)] in which L represents a strong frmw-Iabilizing ligand. Using dimethylsulphoxide as solvent these compounds were not toxic or mutagenic, on the contrary in acetone they were toxic towards all strains of bacteria independently from their excision-repair ability. An entirely different behaviour was exhibited by a second class of compounds having general formula cis-[PtCl2(amine)2] which includes also cis-dichlorodi-ammoniaplatinum(ll) (ds-DDP). These compounds were much less toxic than the previous ones in acetone and were mutagenic; moreover they were able to discriminate between different bacteria strains. Therefore some complexes were active only towards hisG46/pKM101 strain, others towards both hisG46/pKM101 and hisD3052/pKM101 bacteria. Furthermore some compounds (particularly those with H2N-But and H2NCHMePh), differently from ds-DDP, were mutagenic only towards excision-repair deficient strains indicating that they can cause only a specific and well reparable damage.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalToxicological and Environmental Chemistry
Volume8
Issue number1
DOIs
Publication statusPublished - 1984

Keywords

  • mutagenicity
  • Platinum complexes
  • Salmonella
  • solvent effects

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Environmental Science(all)
  • Toxicology

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    Coluccia, M., Correale, M., Giordano, D., Marigglo, M. A., Fanizzi, F. P., Natile, G., Maresca, L., & Tamaro, M. (1984). Mutagenic Activity of Some Platinum Complexes: Chemical Properties and Biological Activity+. Toxicological and Environmental Chemistry, 8(1), 1-8. https://doi.org/10.1080/02772248409357037