The effect of bridging with an ethylene chain the two aminic nitrogens cis-coordinated to the metal in a platinum-dichloro-diamine complex has been examined by studying forward mutagenesis in strains of Salmonella typhimurium carrying hisG46 and hisD3052 mutations and differing at the uvrB locus. While the complexes with the monodentate amines NH3 and α-methylbenzylamine (mba) exhibit strong mutagenic activity, the corresponding species with chelating diamines, 1,2-diaminoethane (en) and N,N′-bis(α-methylbenzyl)1,2-diaminoethane (mben), show much weaker activity. Moreover, the latter complexes appear to be more active via 'frame shift' than 'base substitution' mechanisms and do not differentiate appreciably between cells differing in the rfa locus. Complexes with amines bearing alkyl substituents of opposite chirality (R-mba and S-mba, R,R-mben and S,S-mben) were tested separately and appeared to have comparable activity.
ASJC Scopus subject areas
- Inorganic Chemistry
- Physical and Theoretical Chemistry
- Materials Chemistry