Mutagenic Activity of Transition-Metal Complexes: Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes

Michele Aresta, Sonia Treglia, Mauro Collucia, Mario Correale, Domenico Giordano, Silvana Moscelli

Research output: Contribution to journalArticlepeer-review

Abstract

The inhibitory and mutagenic action of some Pd(II), Pt(II) and Rh(I) complexes towards various bacterial strains has been evaluated, and some correlations have been found between the chemical behaviour of the complexes and their selective biological activity: most of the complexes cause only a DNA damage repaired by the excision repair system. Particularly, the Rh(I) complexes used in this work show selective antibacterial effects on defective but no effect on wild-type strains.

Original languageEnglish
Pages (from-to)81-94
Number of pages14
JournalToxicological and Environmental Chemistry
Volume8
Issue number2-3
DOIs
Publication statusPublished - Jun 1 1984

Keywords

  • bacteria
  • DNA damage
  • mutagenicity
  • palladium complexes
  • Platinum complexes
  • repair systems
  • rhodium complexes

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution
  • Environmental Science(all)
  • Toxicology

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