Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

M. Ferraiuolo, L. Verduci, G. Blandino, S. Strano

Research output: Contribution to journalArticle

Abstract

p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as "the guardian of the genome" and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of developmental and regenerative physiological processes but if deregulated can induce cell transformation and cancer progression. The p53 and Hippo pathways exert a plethora of fine-tuned functions that can apparently be in contrast with each other. In this review, we propose that the p53 status can affect the Hippo pathway function by switching its outputs from tumor suppressor to oncogenic activities. In detail, we discuss: (a) the oncogenic role of the protein complex mutant p53/YAP; (b) TAZ oncogenic activation mediated by mutant p53;
Original languageEnglish
Pages (from-to)E961
JournalInternational Journal of Molecular Sciences
Volume18
Issue number5
DOIs
Publication statusPublished - May 3 2017

Fingerprint

Mutant Proteins
Transducers
transducers
cancer
proteins
Proteins
suppressors
progressions
Tumors
Neoplasms
tumors
Physiological Phenomena
Tumor Suppressor Protein p53
homeostasis
genome
regulators
mutations
coding
Homeostasis
Genes

Keywords

  • Hippo pathway
  • TAZ
  • YAP
  • apoptosis
  • migration
  • mutant p53
  • oncogene
  • proliferation
  • senescence
  • tumor suppressor

Cite this

Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers. / Ferraiuolo, M.; Verduci, L.; Blandino, G.; Strano, S.

In: International Journal of Molecular Sciences, Vol. 18, No. 5, 03.05.2017, p. E961.

Research output: Contribution to journalArticle

@article{d376b1951c024bb39a529e03450cf8cc,
title = "Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers",
abstract = "p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as {"}the guardian of the genome{"} and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of developmental and regenerative physiological processes but if deregulated can induce cell transformation and cancer progression. The p53 and Hippo pathways exert a plethora of fine-tuned functions that can apparently be in contrast with each other. In this review, we propose that the p53 status can affect the Hippo pathway function by switching its outputs from tumor suppressor to oncogenic activities. In detail, we discuss: (a) the oncogenic role of the protein complex mutant p53/YAP; (b) TAZ oncogenic activation mediated by mutant p53;",
keywords = "Hippo pathway, TAZ, YAP, apoptosis, migration, mutant p53, oncogene, proliferation, senescence, tumor suppressor",
author = "M. Ferraiuolo and L. Verduci and G. Blandino and S. Strano",
note = "LR: 20170609; CI: (c) the therapeutic potential of targeting mutant p53 to impair YAP and TAZ oncogenic functions in human cancers.; JID: 101092791; OTO: NOTNLM; 2017/03/02 [received]; 2017/04/11 [revised]; 2017/04/24 [accepted]; epublish",
year = "2017",
month = "5",
day = "3",
doi = "E961 [pii]",
language = "English",
volume = "18",
pages = "E961",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "5",

}

TY - JOUR

T1 - Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

AU - Ferraiuolo, M.

AU - Verduci, L.

AU - Blandino, G.

AU - Strano, S.

N1 - LR: 20170609; CI: (c) the therapeutic potential of targeting mutant p53 to impair YAP and TAZ oncogenic functions in human cancers.; JID: 101092791; OTO: NOTNLM; 2017/03/02 [received]; 2017/04/11 [revised]; 2017/04/24 [accepted]; epublish

PY - 2017/5/3

Y1 - 2017/5/3

N2 - p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as "the guardian of the genome" and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of developmental and regenerative physiological processes but if deregulated can induce cell transformation and cancer progression. The p53 and Hippo pathways exert a plethora of fine-tuned functions that can apparently be in contrast with each other. In this review, we propose that the p53 status can affect the Hippo pathway function by switching its outputs from tumor suppressor to oncogenic activities. In detail, we discuss: (a) the oncogenic role of the protein complex mutant p53/YAP; (b) TAZ oncogenic activation mediated by mutant p53;

AB - p53 protein is a well-known tumor suppressor factor that regulates cellular homeostasis. As it has several and key functions exerted, p53 is known as "the guardian of the genome" and either loss of function or gain of function mutations in the TP53 coding protein sequence are involved in cancer onset and progression. The Hippo pathway is a key regulator of developmental and regenerative physiological processes but if deregulated can induce cell transformation and cancer progression. The p53 and Hippo pathways exert a plethora of fine-tuned functions that can apparently be in contrast with each other. In this review, we propose that the p53 status can affect the Hippo pathway function by switching its outputs from tumor suppressor to oncogenic activities. In detail, we discuss: (a) the oncogenic role of the protein complex mutant p53/YAP; (b) TAZ oncogenic activation mediated by mutant p53;

KW - Hippo pathway

KW - TAZ

KW - YAP

KW - apoptosis

KW - migration

KW - mutant p53

KW - oncogene

KW - proliferation

KW - senescence

KW - tumor suppressor

U2 - E961 [pii]

DO - E961 [pii]

M3 - Article

VL - 18

SP - E961

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 5

ER -