Mutant p53 proteins: Between loss and gain of function

Sabrina Strano, Stefania Dell'Orso, Adriana Maria Mongiovi, Olimpia Monti, Eleonora Lapi, Silvia Di Agostino, Giulia Fontemaggi, Giovanni Blandino

Research output: Contribution to journalArticlepeer-review


Cancer might result from both the aberrant activation of genes, whose physiological tuning is essential for the life of a normal cell, and the inactivation of tumor suppressor genes, whose main job is to preserve the integrity of cell genome. Among the latter, p53 is considered a key tumor suppressor gene that is inactivated mainly by missense mutations in half of human cancers. It is becoming increasingly clear that the resulting mutant p53 proteins gain oncogenic properties favoring the insurgence, the maintenance, and the spreading of malignant tumors. In this review, we mainly discuss the molecular mechanisms underlying gain of function of human tumor-derived p53 mutants, their impact on the chemoresistance and the prognosis of human tumors, with a special focus on head and neck cancers, and the perspectives of treating tumors through the manipulation of mutant p53 proteins.

Original languageEnglish
Pages (from-to)488-496
Number of pages9
JournalHead and Neck
Issue number5
Publication statusPublished - May 2007


  • Anti-cancer treatment
  • Gain of function
  • Mutant p53
  • p53

ASJC Scopus subject areas

  • Otorhinolaryngology

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