Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia

E. Visconti, E. Ortona, P. Mencarini, P. Margutti, S. Marinaci, M. Zolfo, A. Siracusano, Enrica Tamburrini

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to determine whether dihydropteroate synthase gene (DHPS) mutations were associated with the failure of sulpha/sulphone drugs used as prophylaxis agents in HIV infected patients. Results suggested that DHPS mutations were significantly associated with failure of anti-Pneumocystis carinii sulphone prophylaxis (P = 0.031). An increasing number of mutant P. carinii strains have been isolated from patients no longer having prophylaxis. There was no statistically significant difference in severity or outcome of the pneumonia caused by wild-type or mutant DHPS. Moreover, two of the three patients with mutant P. carinii pneumonia (PCP) were successfully treated with sulpha drugs. We think that P. carinii drug-resistance could be an emerging problem for immunocompromised patients including those with HIV infection.

Original languageEnglish
Pages (from-to)547-551
Number of pages5
JournalInternational Journal of Antimicrobial Agents
Volume18
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • Mutations of dihydropteroate synthase gene (DHPS)
  • Pneumocystis carinii
  • Sulpha/sulphone drugs

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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