Mutazioni del gene APOC3, metabolismo dei trigliceridi e riduzione di eventi ischemici cardiovascolari

Translated title of the contribution: Mutations of APOC3 gene, metabolism of triglycerides and reduction of ischemic cardiovascular events

Angela Pirillo, Alberico Luigi Catapano

Research output: Contribution to journalArticlepeer-review

Abstract

A direct relationship between high plasma triglyceride (TG) levels and increased risk of cardiovascular disease has been shown in several studies. TG are present in the blood associated with different lipoprotein classes, including hepatically-derived very low density lipoproteins (VLDL) and intestinally-derived chylomicrons. Lipoprotein lipase (LPL) is a key enzyme that hydrolyzes TG, releasing free fatty acids that accumulate in peripheral tissues and remnant lipoproteins, that are then cleared by the liver. LPL activity is finely modulated by several cofactors, including apolipoprotein C-III (apoC-III) which acts as a LPL inhibitor. The key role of apoC-III has been established in several studies: animal models lacking APOC3 gene exhibit reduced plasma TG levels, whereas the overexpression of APOC3 gene led to increased TG levels. In humans, several mutations in APOC3 gene have been identified, leading to lower apoC-III levels and associated with reduced plasma TG levels. Recently, these mutations were found to be associated with a reduced risk for cardiovascular ischemia and coronary heart disease, thus confirming the negative role of apoC-III in TG metabolism and suggesting apoC-III as possible therapeutic target for the management of hypertriglyceridemia.

Translated title of the contributionMutations of APOC3 gene, metabolism of triglycerides and reduction of ischemic cardiovascular events
Original languageItalian
Pages (from-to)289-294
Number of pages6
JournalGiornale Italiano di Cardiologia
Volume16
Issue number5
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Fingerprint Dive into the research topics of 'Mutations of APOC3 gene, metabolism of triglycerides and reduction of ischemic cardiovascular events'. Together they form a unique fingerprint.

Cite this