Mutual antagonism of T cells causing psoriasis and atopic eczema

Stefanie Eyerich, Anna T. Onken, Stephan Weidinger, Andre Franke, Francesca Nasorri, Davide Pennino, Martine Grosber, Florian Pfab, Carsten B. Schmidt-Weber, Martin Mempel, Ruediger Hein, Johannes Ring, Andrea Cavani, Kilian Eyerich

Research output: Contribution to journalArticlepeer-review

Abstract

The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalNew England Journal of Medicine
Volume365
Issue number3
Publication statusPublished - Jul 21 2011

ASJC Scopus subject areas

  • Medicine(all)

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