We have examined tumor cell DNA content (ploidy) as a possible variable in the behaviour of 75 colorectal cancer treated by surgery. The nuclear DNA content of the neoplasias was measured by a static cytofluorometric method. Fifty-two (69 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). A significant predominance of aneuploid tumors in the left colon and rectum was seen. We found no association between age, pathological stage, histological grade, tumor size and ploidy status. There was a survival advantage to those patients with diploid (and periploid) tumors compared to aneuploid tumors, but this was not as pronounced as previously reported by other authors. It have been seen that when considered individually the factors which were discriminatory were pathological stage and DNA ploidy. However, when considered in conjunction with the other parameters, these two factors remained as independent variables. Therefore, our report supported the hypothesis that nuclear DNA content is an independent prognostic factor in colorectal cancer.
|Translated title of the contribution||Mutual relation between ploidy DNA and prognostic factors in colorectal cancer|
|Number of pages||7|
|Publication status||Published - 1993|
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