CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE

Translated title of the contribution: Mutual relation between ploidy DNA and prognostic factors in colorectal cancer

G. Nicolo, E. Margallo, C. G F Di Somma, M. Gipponi, M. Margiocco, F. Cafiero

Research output: Contribution to journalArticle

Abstract

We have examined tumor cell DNA content (ploidy) as a possible variable in the behaviour of 75 colorectal cancer treated by surgery. The nuclear DNA content of the neoplasias was measured by a static cytofluorometric method. Fifty-two (69 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). A significant predominance of aneuploid tumors in the left colon and rectum was seen. We found no association between age, pathological stage, histological grade, tumor size and ploidy status. There was a survival advantage to those patients with diploid (and periploid) tumors compared to aneuploid tumors, but this was not as pronounced as previously reported by other authors. It have been seen that when considered individually the factors which were discriminatory were pathological stage and DNA ploidy. However, when considered in conjunction with the other parameters, these two factors remained as independent variables. Therefore, our report supported the hypothesis that nuclear DNA content is an independent prognostic factor in colorectal cancer.

Original languageItalian
Pages (from-to)507-513
Number of pages7
JournalChirurgia
Volume6
Issue number9
Publication statusPublished - 1993

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Ploidies
Colorectal Neoplasms
DNA
Aneuploidy
Neoplasms
Diploidy
Rectum
Colon
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Nicolo, G., Margallo, E., Di Somma, C. G. F., Gipponi, M., Margiocco, M., & Cafiero, F. (1993). CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE. Chirurgia, 6(9), 507-513.

CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE. / Nicolo, G.; Margallo, E.; Di Somma, C. G F; Gipponi, M.; Margiocco, M.; Cafiero, F.

In: Chirurgia, Vol. 6, No. 9, 1993, p. 507-513.

Research output: Contribution to journalArticle

Nicolo, G, Margallo, E, Di Somma, CGF, Gipponi, M, Margiocco, M & Cafiero, F 1993, 'CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE', Chirurgia, vol. 6, no. 9, pp. 507-513.
Nicolo G, Margallo E, Di Somma CGF, Gipponi M, Margiocco M, Cafiero F. CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE. Chirurgia. 1993;6(9):507-513.
Nicolo, G. ; Margallo, E. ; Di Somma, C. G F ; Gipponi, M. ; Margiocco, M. ; Cafiero, F. / CORRELAZIONE TRA DNA PLOIDIA E FATTORI PROGNOSTICI NEL CANCRO COLORETTALE. In: Chirurgia. 1993 ; Vol. 6, No. 9. pp. 507-513.
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