Muzolimine: A new high-ceiling diuretic suitable for patients with advanced renal disease

A. Dal Canton, D. Russo, R. Gallo, G. Conte, V. E. Andreucci

Research output: Contribution to journalArticle

Abstract

Muzolimine was administered by mouth to 24 patients with creatinine clearances ranging from 4 to 28 ml/min to treat oedema or hypertension, or both. In four of these 24 patients muzolimine was given after intravenous high-dose frusemide had been unsuccessful. Muzolimine significantly increased urine volume and excretions of sodium, chloride, and potassium ions. Its diuretic efficacy was further shown by a mean reduction in body weight of 8% and by the disappearance of oedema in all affected paients, even those refractory to intravenous frusemide. No rebound phenomenon was observed after the drug was stopped. Mean blood pressure was reduced in all hypertensive patients. Blood pressure was restored to normal in five out of seven patients treated with muzolimine alone and 10 out of 11 in whom muzolimine had been added to previously unsatisfactory antihypertensive treatment. Muzolimine was well tolerated by all patients. Muzolimine appears to be the diuretic of choice when treating patients with advanced renal disease.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalBritish Medical Journal
Volume282
Issue number6264
Publication statusPublished - 1981

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Muzolimine
Sodium Potassium Chloride Symporter Inhibitors
Kidney
Furosemide
Diuretics
Edema
Blood Pressure
Sodium Chloride
Antihypertensive Agents
Mouth
Creatinine
Potassium
Body Weight
Urine
Ions
Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dal Canton, A., Russo, D., Gallo, R., Conte, G., & Andreucci, V. E. (1981). Muzolimine: A new high-ceiling diuretic suitable for patients with advanced renal disease. British Medical Journal, 282(6264), 595-598.

Muzolimine : A new high-ceiling diuretic suitable for patients with advanced renal disease. / Dal Canton, A.; Russo, D.; Gallo, R.; Conte, G.; Andreucci, V. E.

In: British Medical Journal, Vol. 282, No. 6264, 1981, p. 595-598.

Research output: Contribution to journalArticle

Dal Canton, A, Russo, D, Gallo, R, Conte, G & Andreucci, VE 1981, 'Muzolimine: A new high-ceiling diuretic suitable for patients with advanced renal disease', British Medical Journal, vol. 282, no. 6264, pp. 595-598.
Dal Canton A, Russo D, Gallo R, Conte G, Andreucci VE. Muzolimine: A new high-ceiling diuretic suitable for patients with advanced renal disease. British Medical Journal. 1981;282(6264):595-598.
Dal Canton, A. ; Russo, D. ; Gallo, R. ; Conte, G. ; Andreucci, V. E. / Muzolimine : A new high-ceiling diuretic suitable for patients with advanced renal disease. In: British Medical Journal. 1981 ; Vol. 282, No. 6264. pp. 595-598.
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