Abstract
Human acetylcholine receptor and the Lefvert method (13) were used to determine the serum levels of anti-acetylcholine receptor antibodies in 27 patients with Myasthenia Gravis. Antibodies were detected in 22 patients (81%). Negative results were generally obtained in patients having milder forms of the disease. To find out whether serum levels of antibodies correlate with the severity of the disease, we compared the median antibody levels in patients with Type 1 and 2A Myasthenia Gravis with those of patients with type 2B and 3. Significantly lower titers were observed in the first group. Nevertheless, there were many overlapping values in the range of each class of the disease. A more definite relationship was observed in the follow-up of single patients. As a rule, clinical deterioration was accompanied by an increase of antibody levels and viceversa.
| Original language | English |
|---|---|
| Pages (from-to) | 165-171 |
| Number of pages | 7 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jun 1981 |
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Keywords
- Anti-acetylcholine receptor antibodies
- Myasthenia Gravis
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Myasthenia Gravis. Anti-acetylcholine receptor antibodies. / Cerrato, D.; Ariano, C.; La Mantia, L.; Fiacchino, F.; Sghirlanzoni, A.; Nespolo, A.; Corridori, F.; Cornelio, F.
In: Italian Journal of Neurological Sciences, Vol. 2, No. 2, 06.1981, p. 165-171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myasthenia Gravis. Anti-acetylcholine receptor antibodies
AU - Cerrato, D.
AU - Ariano, C.
AU - La Mantia, L.
AU - Fiacchino, F.
AU - Sghirlanzoni, A.
AU - Nespolo, A.
AU - Corridori, F.
AU - Cornelio, F.
PY - 1981/6
Y1 - 1981/6
N2 - Human acetylcholine receptor and the Lefvert method (13) were used to determine the serum levels of anti-acetylcholine receptor antibodies in 27 patients with Myasthenia Gravis. Antibodies were detected in 22 patients (81%). Negative results were generally obtained in patients having milder forms of the disease. To find out whether serum levels of antibodies correlate with the severity of the disease, we compared the median antibody levels in patients with Type 1 and 2A Myasthenia Gravis with those of patients with type 2B and 3. Significantly lower titers were observed in the first group. Nevertheless, there were many overlapping values in the range of each class of the disease. A more definite relationship was observed in the follow-up of single patients. As a rule, clinical deterioration was accompanied by an increase of antibody levels and viceversa.
AB - Human acetylcholine receptor and the Lefvert method (13) were used to determine the serum levels of anti-acetylcholine receptor antibodies in 27 patients with Myasthenia Gravis. Antibodies were detected in 22 patients (81%). Negative results were generally obtained in patients having milder forms of the disease. To find out whether serum levels of antibodies correlate with the severity of the disease, we compared the median antibody levels in patients with Type 1 and 2A Myasthenia Gravis with those of patients with type 2B and 3. Significantly lower titers were observed in the first group. Nevertheless, there were many overlapping values in the range of each class of the disease. A more definite relationship was observed in the follow-up of single patients. As a rule, clinical deterioration was accompanied by an increase of antibody levels and viceversa.
KW - Anti-acetylcholine receptor antibodies
KW - Myasthenia Gravis
UR - http://www.scopus.com/inward/record.url?scp=0019417042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019417042&partnerID=8YFLogxK
U2 - 10.1007/BF02335439
DO - 10.1007/BF02335439
M3 - Article
VL - 2
SP - 165
EP - 171
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 2
ER -