Myasthenia gravis: Recognition of a human autoantigen at the molecular level

Maria Pia Protti, Angelo A. Manfredi, Robert M. Horton, Matteo Bellone, Bianca M. Conti-Tronconi

Research output: Contribution to journalArticle

Abstract

The symptoms of myasthenia gravis are primarily or exclusively due to an autoimmune response against the muscle nicotinic acetylcholine receptor (AChR) and this has been the object of intensive investigations for almost 20 years. A detailed picture at the molecular level of the interaction of this autoantigen with the key elements involved in the autoimmune response, such as anti-AChR antibodies, the T-cell receptor and restricting major histocompatibility complex molecules, is now emerging for both human myasthenia gravis and its experimental model, experimental autoimmune myasthenia gravis. Here, Maria Pia Protti and colleagues focus on the molecular interactions occurring in human myasthenia gravis and summarize recent information on pathogenic mechanisms of the autoimmune response, and the structure of epitopes recognized by B cells and CD4* T cells of myasthenic patients on the AChR molecule.

Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalImmunology Today
Volume14
Issue number7
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology

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