Abstract
The objective was to develop regional domains from the Myasthenia Gravis Questionnaire (MGQ) to better assess generalised, bulbar and ocular involvement in patients with myasthenia gravis (MG) and to evaluate their responsiveness. Some items from the MGQ were aggregated into 3 domains: bulbar, generalised and ocular. The study was carried out at the Institute of Neurology, EMG Service, Università Cattolica, Rome, and the Department of Neurology, University Hospital, Modena, Italy. Ninety-three MG patients were prospectively enrolled in two neurological departments; furthermore, outcome after treatment was studied in 23 patients to evaluate responsiveness. Disease severity was scored according to a modified version of the Osserman classification and MGQ. The questionnaire appeared more sensitive than clinical examination and history to assess bulbar and ocular involvement. For example, according to the bulbar domain, 67 patients experienced bulbar symptoms whereas on clinical examination 51 of 67 were completely normal in the bulbar region. The MGQ domains appeared reliable and sensitive. Results of global MG score (GMG) and of domains appeared reliable. Domains were able to better assess the functional involvement of anatomical regions than main GMG, clinical examination and history.
| Original language | English |
|---|---|
| Pages (from-to) | 331-336 |
| Number of pages | 6 |
| Journal | Neurological Sciences |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Feb 2005 |
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Keywords
- Disease-specific questionnaire
- Domains
- Myasthenia gravis
- Patient-oriented
- Quality of life
- Self-administered questionnaire
- SF-36
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Myasthenia gravis self-administered questionnaire : Development of regional domains. / Padua, L.; Galassi, G.; Ariatti, A.; Aprile, I.; Caliandro, P.; Evoli, A.; Pazzaglia, C.; Tonali, P.
In: Neurological Sciences, Vol. 25, No. 6, 02.2005, p. 331-336.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myasthenia gravis self-administered questionnaire
T2 - Development of regional domains
AU - Padua, L.
AU - Galassi, G.
AU - Ariatti, A.
AU - Aprile, I.
AU - Caliandro, P.
AU - Evoli, A.
AU - Pazzaglia, C.
AU - Tonali, P.
PY - 2005/2
Y1 - 2005/2
N2 - The objective was to develop regional domains from the Myasthenia Gravis Questionnaire (MGQ) to better assess generalised, bulbar and ocular involvement in patients with myasthenia gravis (MG) and to evaluate their responsiveness. Some items from the MGQ were aggregated into 3 domains: bulbar, generalised and ocular. The study was carried out at the Institute of Neurology, EMG Service, Università Cattolica, Rome, and the Department of Neurology, University Hospital, Modena, Italy. Ninety-three MG patients were prospectively enrolled in two neurological departments; furthermore, outcome after treatment was studied in 23 patients to evaluate responsiveness. Disease severity was scored according to a modified version of the Osserman classification and MGQ. The questionnaire appeared more sensitive than clinical examination and history to assess bulbar and ocular involvement. For example, according to the bulbar domain, 67 patients experienced bulbar symptoms whereas on clinical examination 51 of 67 were completely normal in the bulbar region. The MGQ domains appeared reliable and sensitive. Results of global MG score (GMG) and of domains appeared reliable. Domains were able to better assess the functional involvement of anatomical regions than main GMG, clinical examination and history.
AB - The objective was to develop regional domains from the Myasthenia Gravis Questionnaire (MGQ) to better assess generalised, bulbar and ocular involvement in patients with myasthenia gravis (MG) and to evaluate their responsiveness. Some items from the MGQ were aggregated into 3 domains: bulbar, generalised and ocular. The study was carried out at the Institute of Neurology, EMG Service, Università Cattolica, Rome, and the Department of Neurology, University Hospital, Modena, Italy. Ninety-three MG patients were prospectively enrolled in two neurological departments; furthermore, outcome after treatment was studied in 23 patients to evaluate responsiveness. Disease severity was scored according to a modified version of the Osserman classification and MGQ. The questionnaire appeared more sensitive than clinical examination and history to assess bulbar and ocular involvement. For example, according to the bulbar domain, 67 patients experienced bulbar symptoms whereas on clinical examination 51 of 67 were completely normal in the bulbar region. The MGQ domains appeared reliable and sensitive. Results of global MG score (GMG) and of domains appeared reliable. Domains were able to better assess the functional involvement of anatomical regions than main GMG, clinical examination and history.
KW - Disease-specific questionnaire
KW - Domains
KW - Myasthenia gravis
KW - Patient-oriented
KW - Quality of life
KW - Self-administered questionnaire
KW - SF-36
UR - http://www.scopus.com/inward/record.url?scp=14844292550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14844292550&partnerID=8YFLogxK
U2 - 10.1007/s10072-004-0366-5
DO - 10.1007/s10072-004-0366-5
M3 - Article
VL - 25
SP - 331
EP - 336
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -