Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review

Paolo Emilio Alboini, Valentina Damato, Raffaele Iorio, Marco Luigetti, Amelia Evoli

Research output: Contribution to journalArticlepeer-review

Abstract

The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies.We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies.

Original languageEnglish
Pages (from-to)646-650
Number of pages5
JournalNeuromuscular Disorders
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • 3,4-Diaminopyridine
  • Cholinesterase inhibitors
  • Lambert-Eaton myasthenic syndrome
  • Myasthenia gravis
  • Presynaptic neurophysiological pattern

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)
  • Neurology

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