The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies.We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies.
- Cholinesterase inhibitors
- Lambert-Eaton myasthenic syndrome
- Myasthenia gravis
- Presynaptic neurophysiological pattern
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health