Abstract
We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.
| Original language | English |
|---|---|
| Pages (from-to) | 45-47 |
| Number of pages | 3 |
| Journal | Annals of Hematology |
| Volume | 76 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1998 |
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Keywords
- B-CLL
- IgH gene rearrangement
- Myasthenic syndrome
- Neoplastic progression
- Seminested PCR
ASJC Scopus subject areas
- Hematology
Cite this
Myasthenic syndrome and oligoclonal lymphocytosis : Evolution into chronic lymphocytic leukemia. / Radossi, P.; Dazzi, F.; De Franchis, G.; Vianello, F.; Tison, T.; Menin, C.; Montagna, M.; D'Andrea, E.
In: Annals of Hematology, Vol. 76, No. 1, 01.1998, p. 45-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myasthenic syndrome and oligoclonal lymphocytosis
T2 - Evolution into chronic lymphocytic leukemia
AU - Radossi, P.
AU - Dazzi, F.
AU - De Franchis, G.
AU - Vianello, F.
AU - Tison, T.
AU - Menin, C.
AU - Montagna, M.
AU - D'Andrea, E.
PY - 1998/1
Y1 - 1998/1
N2 - We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.
AB - We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.
KW - B-CLL
KW - IgH gene rearrangement
KW - Myasthenic syndrome
KW - Neoplastic progression
KW - Seminested PCR
UR - http://www.scopus.com/inward/record.url?scp=0031985755&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031985755&partnerID=8YFLogxK
U2 - 10.1007/s002770050360
DO - 10.1007/s002770050360
M3 - Article
C2 - 9486925
AN - SCOPUS:0031985755
VL - 76
SP - 45
EP - 47
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 1
ER -