Myasthenic syndrome and oligoclonal lymphocytosis

Evolution into chronic lymphocytic leukemia

P. Radossi, F. Dazzi, G. De Franchis, F. Vianello, T. Tison, C. Menin, M. Montagna, E. D'Andrea

Research output: Contribution to journalArticle

Abstract

We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalAnnals of Hematology
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 1998

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Lymphocytosis
Muscle Weakness
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Clone Cells
Immunoglobulin Heavy Chain Genes
Immunoglobulin Light Chains
Neoplastic Processes
Gene Rearrangement
Leukocyte Count
Autoimmune Diseases
Immune System

Keywords

  • B-CLL
  • IgH gene rearrangement
  • Myasthenic syndrome
  • Neoplastic progression
  • Seminested PCR

ASJC Scopus subject areas

  • Hematology

Cite this

Radossi, P., Dazzi, F., De Franchis, G., Vianello, F., Tison, T., Menin, C., ... D'Andrea, E. (1998). Myasthenic syndrome and oligoclonal lymphocytosis: Evolution into chronic lymphocytic leukemia. Annals of Hematology, 76(1), 45-47. https://doi.org/10.1007/s002770050360

Myasthenic syndrome and oligoclonal lymphocytosis : Evolution into chronic lymphocytic leukemia. / Radossi, P.; Dazzi, F.; De Franchis, G.; Vianello, F.; Tison, T.; Menin, C.; Montagna, M.; D'Andrea, E.

In: Annals of Hematology, Vol. 76, No. 1, 01.1998, p. 45-47.

Research output: Contribution to journalArticle

Radossi, P. ; Dazzi, F. ; De Franchis, G. ; Vianello, F. ; Tison, T. ; Menin, C. ; Montagna, M. ; D'Andrea, E. / Myasthenic syndrome and oligoclonal lymphocytosis : Evolution into chronic lymphocytic leukemia. In: Annals of Hematology. 1998 ; Vol. 76, No. 1. pp. 45-47.
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