Myasthenic syndrome and oligoclonal lymphocytosis: Evolution into chronic lymphocytic leukemia

P. Radossi, F. Dazzi, G. De Franchis, F. Vianello, T. Tison, C. Menin, M. Montagna, E. D'Andrea

Research output: Contribution to journalArticle

Abstract

We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalAnnals of Hematology
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 1998

Keywords

  • B-CLL
  • IgH gene rearrangement
  • Myasthenic syndrome
  • Neoplastic progression
  • Seminested PCR

ASJC Scopus subject areas

  • Hematology

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