Myasthenic syndrome and oligoclonal lymphocytosis: Evolution into chronic lymphocytic leukemia

P. Radossi; F. Dazzi; G. De Franchis; F. Vianello; T. Tison; C. Menin; M. Montagna; E. D'Andrea

doi:10.1007/s002770050360

Myasthenic syndrome and oligoclonal lymphocytosis: Evolution into chronic lymphocytic leukemia

P. Radossi, F. Dazzi, G. De Franchis, F. Vianello, T. Tison, C. Menin, M. Montagna, E. D'Andrea

Istituto Oncologico Veneto

Research output: Contribution to journal › Article

Abstract

We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.

Original language	English
Pages (from-to)	45-47
Number of pages	3
Journal	Annals of Hematology
Volume	76
Issue number	1
DOIs	https://doi.org/10.1007/s002770050360
Publication status	Published - Jan 1998

Keywords

B-CLL
IgH gene rearrangement
Myasthenic syndrome
Neoplastic progression
Seminested PCR

ASJC Scopus subject areas

Hematology

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10.1007/s002770050360

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abstract = "We report a patient with myasthenic syndrome who, 2 years after diagnosis, developed an oligoclonal lymphocytosis. This disorder was sustained by both κ+ and λ+ CD5+ B-cell clones; over the following year, the white blood cell count increased and phenotypic characterization revealed a clear imbalance in the immunoglobulin light chain ratio (84% κ+). Accordingly, persistence of a κ+ B-cell clone was disclosed by molecular analysis of immunoglobulin heavy chain gene rearrangements. Our results may suggest that prolonged immune system stimulation due to an autoimmune disease can drive a benign lymphoproliferation into a B-cell neoplastic process.",

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AU - Radossi, P.

AU - Dazzi, F.

AU - De Franchis, G.

AU - Vianello, F.

AU - Tison, T.

AU - Menin, C.

AU - Montagna, M.

AU - D'Andrea, E.

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