Mycobacteria and dendritic cell differentiation: Escape or control of immunity

Angelo Martino, Alessandra Sacchi, Vittorio Colizzi, Silvia Vendetti

Research output: Contribution to journalArticle

Abstract

Human monocytes can differentiate into dendritic cells (DC) according to the nature of environmental signals. Pathogenic mycobacteria have been demonstrated interfere with this process to generate a not fully competent DC population. This mechanism is not common to non-pathogenic mycobacteria and could be correlated with bacterial virulence. However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections.

Original languageEnglish
Pages (from-to)115-117
Number of pages3
JournalImmunology Letters
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 15 2006

Keywords

  • Dendritic cells
  • Monocyte differentiation
  • Mycobacteria

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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