Mycobacteria and dendritic cell differentiation: Escape or control of immunity

Angelo Martino; Alessandra Sacchi; Vittorio Colizzi; Silvia Vendetti

doi:10.1016/j.imlet.2005.06.016

Mycobacteria and dendritic cell differentiation: Escape or control of immunity

Angelo Martino, Alessandra Sacchi, Vittorio Colizzi, Silvia Vendetti

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Human monocytes can differentiate into dendritic cells (DC) according to the nature of environmental signals. Pathogenic mycobacteria have been demonstrated interfere with this process to generate a not fully competent DC population. This mechanism is not common to non-pathogenic mycobacteria and could be correlated with bacterial virulence. However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections.

Original language	English
Pages (from-to)	115-117
Number of pages	3
Journal	Immunology Letters
Volume	102
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.06.016
Publication status	Published - Jan 15 2006

Keywords

Dendritic cells
Monocyte differentiation
Mycobacteria

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.imlet.2005.06.016

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abstract = "Human monocytes can differentiate into dendritic cells (DC) according to the nature of environmental signals. Pathogenic mycobacteria have been demonstrated interfere with this process to generate a not fully competent DC population. This mechanism is not common to non-pathogenic mycobacteria and could be correlated with bacterial virulence. However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections.",

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AU - Sacchi, Alessandra

AU - Colizzi, Vittorio

AU - Vendetti, Silvia

PY - 2006/1/15

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N2 - Human monocytes can differentiate into dendritic cells (DC) according to the nature of environmental signals. Pathogenic mycobacteria have been demonstrated interfere with this process to generate a not fully competent DC population. This mechanism is not common to non-pathogenic mycobacteria and could be correlated with bacterial virulence. However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections.

AB - Human monocytes can differentiate into dendritic cells (DC) according to the nature of environmental signals. Pathogenic mycobacteria have been demonstrated interfere with this process to generate a not fully competent DC population. This mechanism is not common to non-pathogenic mycobacteria and could be correlated with bacterial virulence. However, it could represents a new mechanism of immune escape by persistent pathogens or a control mechanism of immune system to preserve the life of the organ against persistent infections.

KW - Dendritic cells

KW - Monocyte differentiation

KW - Mycobacteria

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Mycobacteria and dendritic cell differentiation: Escape or control of immunity

Abstract

Keywords

ASJC Scopus subject areas

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