Abstract
The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994-1998 a median of 160 days after transplantation. The mean interval between first symptoms and diagnosis was 29 days and was still longer for patients with atypical MBI or recipients of corticosteroid therapy. The prevalence of MBI was highest among those who received matched unrelated or mismatched STCs from related donors. Of 31 patients, 20 had tuberculosis, 8 had atypical MBI, and 3 had diagnoses based on histological findings only. Five patients (16%) died, all of whom had received an allogeneic SCT. Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients.
| Original language | English |
|---|---|
| Pages (from-to) | 1229-1236 |
| Number of pages | 8 |
| Journal | Clinical Infectious Diseases |
| Volume | 38 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - May 1 2004 |
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ASJC Scopus subject areas
- Immunology
Cite this
Mycobacterial infection : A difficult and late diagnosis in stem cell transplant recipients. / Cordonnier, C.; Martino, R.; Trabasso, P.; Held, T. K.; Akan, H.; Ward, M. S.; Fabian, K.; Ullmann, A. J.; Wulffraat, N.; Ljungman, P.; Alessandrino, E. P.; Pretnar, J.; Gmür, J.; Varela, R.; Vitek, A.; Sica, S.; Rovira, M.
In: Clinical Infectious Diseases, Vol. 38, No. 9, 01.05.2004, p. 1229-1236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mycobacterial infection
T2 - A difficult and late diagnosis in stem cell transplant recipients
AU - Cordonnier, C.
AU - Martino, R.
AU - Trabasso, P.
AU - Held, T. K.
AU - Akan, H.
AU - Ward, M. S.
AU - Fabian, K.
AU - Ullmann, A. J.
AU - Wulffraat, N.
AU - Ljungman, P.
AU - Alessandrino, E. P.
AU - Pretnar, J.
AU - Gmür, J.
AU - Varela, R.
AU - Vitek, A.
AU - Sica, S.
AU - Rovira, M.
PY - 2004/5/1
Y1 - 2004/5/1
N2 - The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994-1998 a median of 160 days after transplantation. The mean interval between first symptoms and diagnosis was 29 days and was still longer for patients with atypical MBI or recipients of corticosteroid therapy. The prevalence of MBI was highest among those who received matched unrelated or mismatched STCs from related donors. Of 31 patients, 20 had tuberculosis, 8 had atypical MBI, and 3 had diagnoses based on histological findings only. Five patients (16%) died, all of whom had received an allogeneic SCT. Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients.
AB - The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994-1998 a median of 160 days after transplantation. The mean interval between first symptoms and diagnosis was 29 days and was still longer for patients with atypical MBI or recipients of corticosteroid therapy. The prevalence of MBI was highest among those who received matched unrelated or mismatched STCs from related donors. Of 31 patients, 20 had tuberculosis, 8 had atypical MBI, and 3 had diagnoses based on histological findings only. Five patients (16%) died, all of whom had received an allogeneic SCT. Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients.
UR - http://www.scopus.com/inward/record.url?scp=2342506450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2342506450&partnerID=8YFLogxK
U2 - 10.1086/383307
DO - 10.1086/383307
M3 - Article
VL - 38
SP - 1229
EP - 1236
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 9
ER -