Mycobacterial infection

A difficult and late diagnosis in stem cell transplant recipients

C. Cordonnier, R. Martino, P. Trabasso, T. K. Held, H. Akan, M. S. Ward, K. Fabian, A. J. Ullmann, N. Wulffraat, P. Ljungman, E. P. Alessandrino, J. Pretnar, J. Gmür, R. Varela, A. Vitek, S. Sica, M. Rovira

Research output: Contribution to journalArticle

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Abstract

The Infectious Diseases Working Party of the European Blood and Marrow Transplant Group conducted a survey to obtain information about the frequency, presentation, and treatment of mycobacterial infection (MBI) in stem cell transplant (SCT) recipients. Among 29 centers, MBI was diagnosed in 0.79% of 1513 allogeneic and 0.23% of 3012 autologous SCT recipients during 1994-1998 a median of 160 days after transplantation. The mean interval between first symptoms and diagnosis was 29 days and was still longer for patients with atypical MBI or recipients of corticosteroid therapy. The prevalence of MBI was highest among those who received matched unrelated or mismatched STCs from related donors. Of 31 patients, 20 had tuberculosis, 8 had atypical MBI, and 3 had diagnoses based on histological findings only. Five patients (16%) died, all of whom had received an allogeneic SCT. Because of the increased numbers of unmatched donors and transplantation programs in countries with a high prevalence of tuberculosis, constant vigilance is required to early detect MBI in SCT recipients.

Original languageEnglish
Pages (from-to)1229-1236
Number of pages8
JournalClinical Infectious Diseases
Volume38
Issue number9
DOIs
Publication statusPublished - May 1 2004

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Delayed Diagnosis
Stem Cells
Transplants
Infection
Tuberculosis
Transplantation
Tissue Donors
Communicable Diseases
Transplant Recipients
Adrenal Cortex Hormones
Bone Marrow
Therapeutics

ASJC Scopus subject areas

  • Immunology

Cite this

Cordonnier, C., Martino, R., Trabasso, P., Held, T. K., Akan, H., Ward, M. S., ... Rovira, M. (2004). Mycobacterial infection: A difficult and late diagnosis in stem cell transplant recipients. Clinical Infectious Diseases, 38(9), 1229-1236. https://doi.org/10.1086/383307

Mycobacterial infection : A difficult and late diagnosis in stem cell transplant recipients. / Cordonnier, C.; Martino, R.; Trabasso, P.; Held, T. K.; Akan, H.; Ward, M. S.; Fabian, K.; Ullmann, A. J.; Wulffraat, N.; Ljungman, P.; Alessandrino, E. P.; Pretnar, J.; Gmür, J.; Varela, R.; Vitek, A.; Sica, S.; Rovira, M.

In: Clinical Infectious Diseases, Vol. 38, No. 9, 01.05.2004, p. 1229-1236.

Research output: Contribution to journalArticle

Cordonnier, C, Martino, R, Trabasso, P, Held, TK, Akan, H, Ward, MS, Fabian, K, Ullmann, AJ, Wulffraat, N, Ljungman, P, Alessandrino, EP, Pretnar, J, Gmür, J, Varela, R, Vitek, A, Sica, S & Rovira, M 2004, 'Mycobacterial infection: A difficult and late diagnosis in stem cell transplant recipients', Clinical Infectious Diseases, vol. 38, no. 9, pp. 1229-1236. https://doi.org/10.1086/383307
Cordonnier C, Martino R, Trabasso P, Held TK, Akan H, Ward MS et al. Mycobacterial infection: A difficult and late diagnosis in stem cell transplant recipients. Clinical Infectious Diseases. 2004 May 1;38(9):1229-1236. https://doi.org/10.1086/383307
Cordonnier, C. ; Martino, R. ; Trabasso, P. ; Held, T. K. ; Akan, H. ; Ward, M. S. ; Fabian, K. ; Ullmann, A. J. ; Wulffraat, N. ; Ljungman, P. ; Alessandrino, E. P. ; Pretnar, J. ; Gmür, J. ; Varela, R. ; Vitek, A. ; Sica, S. ; Rovira, M. / Mycobacterial infection : A difficult and late diagnosis in stem cell transplant recipients. In: Clinical Infectious Diseases. 2004 ; Vol. 38, No. 9. pp. 1229-1236.
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