TY - JOUR
T1 - Mycobacterium shigaense sp. nov., a novel slowly growing scotochromogenic mycobacterium that produced nodules in an erythroderma patient with severe cellular immunodeficiency and a history of Hodgkin's disease
AU - Nakanaga, Kazue
AU - Hoshino, Yoshihiko
AU - Wakabayashi, Makiko
AU - Fujimoto, Noriki
AU - Tortoli, Enrico
AU - Makino, Masahiko
AU - Tanaka, Toshihiro
AU - Ishii, Norihisa
PY - 2012/4
Y1 - 2012/4
N2 - A novel slow-growing scotochromogenic mycobacterium was isolated from skin biopsies from a patient with a history of Hodgkin's disease and severe cellular immunodeficiency as an opportunistic pathogen. Clinical characterization of these lesions revealed papules and nodules with pathological granuloma formation. Genotypic analysis using 16S rRNA misidentified this isolate as Mycobacterium simiae. However, multiple gene analysis using the internal transcribed spacer between the 16S and 23S rRNA genes, and the rpoB and hsp65 genes revealed the presence of a novel mycobacterium. The antimicrobial susceptibility of this isolate was completely different from that of M. simiae. On the basis of these findings, we propose naming this new species Mycobacterium shigaense sp. nov., and conclude that multiple gene analysis is required for the appropriate diagnosis and treatment of non-tuberculous mycobacterial infections.
AB - A novel slow-growing scotochromogenic mycobacterium was isolated from skin biopsies from a patient with a history of Hodgkin's disease and severe cellular immunodeficiency as an opportunistic pathogen. Clinical characterization of these lesions revealed papules and nodules with pathological granuloma formation. Genotypic analysis using 16S rRNA misidentified this isolate as Mycobacterium simiae. However, multiple gene analysis using the internal transcribed spacer between the 16S and 23S rRNA genes, and the rpoB and hsp65 genes revealed the presence of a novel mycobacterium. The antimicrobial susceptibility of this isolate was completely different from that of M. simiae. On the basis of these findings, we propose naming this new species Mycobacterium shigaense sp. nov., and conclude that multiple gene analysis is required for the appropriate diagnosis and treatment of non-tuberculous mycobacterial infections.
KW - cellular immunodeficiency
KW - Mycobacterium shigaense sp.nov.
KW - non-tuberculous mycobacteria
KW - opportunistic infection
UR - http://www.scopus.com/inward/record.url?scp=84863339408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863339408&partnerID=8YFLogxK
U2 - 10.1111/j.1346-8138.2011.01355.x
DO - 10.1111/j.1346-8138.2011.01355.x
M3 - Article
C2 - 21955184
AN - SCOPUS:84863339408
VL - 39
SP - 389
EP - 396
JO - Journal of Dermatology
JF - Journal of Dermatology
SN - 0385-2407
IS - 4
ER -