Mycobacterium shigaense sp. nov., a novel slowly growing scotochromogenic mycobacterium that produced nodules in an erythroderma patient with severe cellular immunodeficiency and a history of Hodgkin's disease

Kazue Nakanaga, Yoshihiko Hoshino, Makiko Wakabayashi, Noriki Fujimoto, Enrico Tortoli, Masahiko Makino, Toshihiro Tanaka, Norihisa Ishii

Research output: Contribution to journalArticlepeer-review

Abstract

A novel slow-growing scotochromogenic mycobacterium was isolated from skin biopsies from a patient with a history of Hodgkin's disease and severe cellular immunodeficiency as an opportunistic pathogen. Clinical characterization of these lesions revealed papules and nodules with pathological granuloma formation. Genotypic analysis using 16S rRNA misidentified this isolate as Mycobacterium simiae. However, multiple gene analysis using the internal transcribed spacer between the 16S and 23S rRNA genes, and the rpoB and hsp65 genes revealed the presence of a novel mycobacterium. The antimicrobial susceptibility of this isolate was completely different from that of M. simiae. On the basis of these findings, we propose naming this new species Mycobacterium shigaense sp. nov., and conclude that multiple gene analysis is required for the appropriate diagnosis and treatment of non-tuberculous mycobacterial infections.

Original languageEnglish
Pages (from-to)389-396
Number of pages8
JournalJournal of Dermatology
Volume39
Issue number4
DOIs
Publication statusPublished - Apr 2012

Keywords

  • cellular immunodeficiency
  • Mycobacterium shigaense sp.nov.
  • non-tuberculous mycobacteria
  • opportunistic infection

ASJC Scopus subject areas

  • Dermatology

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