TY - JOUR
T1 - Mycobacterium tuberculosis is selectively killed by rifampin and rifapentine in hypoxia at neutral pH
AU - Iacobino, Angelo
AU - Piccaro, Giovanni
AU - Giannoni, Federico
AU - Mustazzolu, Alessandro
AU - Fattorini, Lanfranco
PY - 2017/3/1
Y1 - 2017/3/1
N2 - The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide, isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested against nonreplicating (dormant) Mycobacterium tuberculosis H37Rv under conditions of hypoxia at pHs 5.8 and 7.3, mimicking environments of cellular granulomas and caseous granulomas, respectively. At pH 5.8, several drugs killed dormant bacilli, with the best being rifampin and rifapentine. At pH 7.3, only rifampin and rifapentine efficiently killed dormant bacilli, while all other drugs showed little activity.
AB - The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide, isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested against nonreplicating (dormant) Mycobacterium tuberculosis H37Rv under conditions of hypoxia at pHs 5.8 and 7.3, mimicking environments of cellular granulomas and caseous granulomas, respectively. At pH 5.8, several drugs killed dormant bacilli, with the best being rifampin and rifapentine. At pH 7.3, only rifampin and rifapentine efficiently killed dormant bacilli, while all other drugs showed little activity.
KW - Dormancy
KW - Hypoxia
KW - Killing
KW - Mycobacterium tuberculosis
KW - pH
KW - Rifampin
KW - Rifapentine
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85014108524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014108524&partnerID=8YFLogxK
U2 - 10.1128/AAC.02296-16
DO - 10.1128/AAC.02296-16
M3 - Article
C2 - 27993848
AN - SCOPUS:85014108524
VL - 61
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 3
M1 - e02296
ER -