Abstract
The activities of rifampin, rifapentine, bedaquiline, PA-824, clofazimine, nitazoxanide, isoniazid, amikacin, moxifloxacin, niclosamide, thioridazine, and pyrazinamide were tested against nonreplicating (dormant) Mycobacterium tuberculosis H37Rv under conditions of hypoxia at pHs 5.8 and 7.3, mimicking environments of cellular granulomas and caseous granulomas, respectively. At pH 5.8, several drugs killed dormant bacilli, with the best being rifampin and rifapentine. At pH 7.3, only rifampin and rifapentine efficiently killed dormant bacilli, while all other drugs showed little activity.
| Original language | English |
|---|---|
| Article number | e02296 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 61 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2017 |
Keywords
- Dormancy
- Hypoxia
- Killing
- Mycobacterium tuberculosis
- pH
- Rifampin
- Rifapentine
- Tuberculosis
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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Cite this
Iacobino, A., Piccaro, G., Giannoni, F., Mustazzolu, A., & Fattorini, L. (2017). Mycobacterium tuberculosis is selectively killed by rifampin and rifapentine in hypoxia at neutral pH. Antimicrobial Agents and Chemotherapy, 61(3), [e02296]. https://doi.org/10.1128/AAC.02296-16