Abstract
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
| Original language | English |
|---|---|
| Journal | Nature Genetics |
| DOIs | |
| Publication status | Accepted/In press - Oct 31 2016 |
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ASJC Scopus subject areas
- Genetics
Cite this
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. / Stucki, David; Brites, Daniela; Jeljeli, Leïla; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, Sonia; Luo, Tao; Gao, Qian; Kato-Maeda, Midori; Ballif, Marie; Egger, Matthias; Macedo, Rita; Mardassi, Helmi; Moreno, Milagros; Vilanova, Griselda Tudo; Fyfe, Janet; Globan, Maria; Thomas, Jackson; Jamieson, Frances; Guthrie, Jennifer L.; Asante-Poku, Adwoa; Yeboah-Manu, Dorothy; Wampande, Eddie; Ssengooba, Willy; Joloba, Moses; Boom, W. Henry; Basu, Indira; Bower, James; Saraiva, Margarida; Vasconcellos, Sidra E G; Suffys, Philip; Koch, Anastasia; Wilkinson, Robert; Gail-Bekker, Linda; Malla, Bijaya; Ley, Serej D.; Beck, Hans Peter; de Jong, Bouke C.; Toit, Kadri; Sanchez-Padilla, Elisabeth; Bonnet, Maryline; Gil-Brusola, Ana; Frank, Matthias; Penlap Beng, Veronique N.; Eisenach, Kathleen; Alani, Issam; Ndung'u, Perpetual Wangui; Revathi, Gunturu; Gehre, Florian; Akter, Suriya; Ntoumi, Francine; Stewart-Isherwood, Lynsey; Ntinginya, Nyanda E.; Rachow, Andrea; Hoelscher, Michael; Cirillo, Daniela Maria; Skenders, Girts; Hoffner, Sven; Bakonyte, Daiva; Stakenas, Petras; Diel, Roland; Crudu, Valeriu; Moldovan, Olga; Al-Hajoj, Sahal; Otero, Larissa; Barletta, Francesca; Carter, E. Jane; Diero, Lameck; Supply, Philip; Comas, Iñaki; Niemann, Stefan; Gagneux, Sebastien.
In: Nature Genetics, 31.10.2016.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
AU - Stucki, David
AU - Brites, Daniela
AU - Jeljeli, Leïla
AU - Coscolla, Mireia
AU - Liu, Qingyun
AU - Trauner, Andrej
AU - Fenner, Lukas
AU - Rutaihwa, Liliana
AU - Borrell, Sonia
AU - Luo, Tao
AU - Gao, Qian
AU - Kato-Maeda, Midori
AU - Ballif, Marie
AU - Egger, Matthias
AU - Macedo, Rita
AU - Mardassi, Helmi
AU - Moreno, Milagros
AU - Vilanova, Griselda Tudo
AU - Fyfe, Janet
AU - Globan, Maria
AU - Thomas, Jackson
AU - Jamieson, Frances
AU - Guthrie, Jennifer L.
AU - Asante-Poku, Adwoa
AU - Yeboah-Manu, Dorothy
AU - Wampande, Eddie
AU - Ssengooba, Willy
AU - Joloba, Moses
AU - Boom, W. Henry
AU - Basu, Indira
AU - Bower, James
AU - Saraiva, Margarida
AU - Vasconcellos, Sidra E G
AU - Suffys, Philip
AU - Koch, Anastasia
AU - Wilkinson, Robert
AU - Gail-Bekker, Linda
AU - Malla, Bijaya
AU - Ley, Serej D.
AU - Beck, Hans Peter
AU - de Jong, Bouke C.
AU - Toit, Kadri
AU - Sanchez-Padilla, Elisabeth
AU - Bonnet, Maryline
AU - Gil-Brusola, Ana
AU - Frank, Matthias
AU - Penlap Beng, Veronique N.
AU - Eisenach, Kathleen
AU - Alani, Issam
AU - Ndung'u, Perpetual Wangui
AU - Revathi, Gunturu
AU - Gehre, Florian
AU - Akter, Suriya
AU - Ntoumi, Francine
AU - Stewart-Isherwood, Lynsey
AU - Ntinginya, Nyanda E.
AU - Rachow, Andrea
AU - Hoelscher, Michael
AU - Cirillo, Daniela Maria
AU - Skenders, Girts
AU - Hoffner, Sven
AU - Bakonyte, Daiva
AU - Stakenas, Petras
AU - Diel, Roland
AU - Crudu, Valeriu
AU - Moldovan, Olga
AU - Al-Hajoj, Sahal
AU - Otero, Larissa
AU - Barletta, Francesca
AU - Carter, E. Jane
AU - Diero, Lameck
AU - Supply, Philip
AU - Comas, Iñaki
AU - Niemann, Stefan
AU - Gagneux, Sebastien
PY - 2016/10/31
Y1 - 2016/10/31
N2 - Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
AB - Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
UR - http://www.scopus.com/inward/record.url?scp=84992759009&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84992759009&partnerID=8YFLogxK
U2 - 10.1038/ng.3704
DO - 10.1038/ng.3704
M3 - Article
AN - SCOPUS:84992759009
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
ER -