Mycophenolate mofetil in primary glomerulopathies

V. Sepe, C. Libetta, M. G. Giuliano, G. Adamo, A. Dal Canton

Research output: Contribution to journalArticle

Abstract

Mycophenolate mofetil is an immunosuppressive agent that blocks purine biosynthesis, inhibits T and B-lymphocyte and mesangial proliferation. Mycophenolate mofetil is not nephrotoxic like calcineurin inhibitors and is widely used in solid-organ transplantation. Recently, mycophenolate mofetil has been introduced in the treatment of autoimmune diseases and primary glomerulopathies. This review analyzes the literature currently available on the treatment of primary glomerulopathies with mycophenolate mofetil. Encouraging results have been obtained in minimal change nephropathy where it may help to reduce the use of steroids in these patients who are often very young. The results obtained in medium and high risk patients with focal segmental glomerulonephritis and idiopathic membranous nephropathy were less encouraging. Conflicting results have been reported on IgA nephropathy in controlled trials. None of these studies attained level A evidence, meaning that randomized control trials of sufficient statistical significance are necessary to estimate the real effectiveness of mycophenolate mofetil in primary glomerulopathies.

Original languageEnglish
Pages (from-to)154-162
Number of pages9
JournalKidney International
Volume73
Issue number2
DOIs
Publication statusPublished - Jan 10 2008

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Keywords

  • Focal segmental glomerulosclerosis
  • Idiopathic membranous nephropathy
  • IgA nephropathy
  • Minimal change nephropathy
  • Mycophenolate mofetil
  • Steroids

ASJC Scopus subject areas

  • Nephrology

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