Mycoplasma genitalium in males with nongonococcal urethritis

Prevalence and clinical efficacy of eradication

Daniele Gambini, Irene Decleva, Loredana Lupica, Massimo Ghislanzoni, Marco Cusini, Elvio Alessi

Research output: Contribution to journalArticle

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Abstract

Background: Mycoplasma genitalium is regarded as a potential pathogen of the human urogenital tract based on prevalence findings of several European studies. Goal: To determine the prevalence of M genitalium in urethral specimens of symptomatic patients with nongonococcal urethritis and from asymptomatic patients attending a sexually transmitted disease clinic in Milan, and to verify the clinical efficacy of M genitalium eradication by antibiotic treatment. Study Design: From May 1998 to late April 1999, a routine analysis for M genitalium by DNA amplification (polymerase chain reaction) was performed in patients attending the Institute of Dermatological Science in Milan. The authors examined urethral swabs from 178 symptomatic and 23 asymptomatic males. M genitalium-positive patients were clinically and microbiologically tested after treatment with either doxycycline or azithromycin. Results: Among males with nongonococcal urethritis, M genitalium was detected in 14.0% of patients as the only agent; in 15.1% of patients in association with Chlamydia trachomatis and/or Ureaplasma urealyticum; and in 1 asymptomatic patient. In all symptomatic M genitalium- positive patients, antibiotic treatment eradicated the infection and cured Clinical symptoms. Conclusion: These data reveal the high prevalence of M genitalium in symptomatic patients, the rarity of asymptomatic carriers, the high susceptibility to antibiotic treatment, and the clinical efficacy of M genitalium eradication. Moreover, data confirm the etiologic role of M genitalium in inflammatory processes of the human urogenital tract in the Mediterranean area.

Original languageEnglish
Pages (from-to)226-229
Number of pages4
JournalSexually Transmitted Diseases
Volume27
Issue number4
Publication statusPublished - Apr 2000

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Mycoplasma genitalium
Urethritis
Anti-Bacterial Agents
Ureaplasma urealyticum
Azithromycin
Doxycycline
Chlamydia trachomatis
DNA-Directed DNA Polymerase
Sexually Transmitted Diseases
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)

Cite this

Mycoplasma genitalium in males with nongonococcal urethritis : Prevalence and clinical efficacy of eradication. / Gambini, Daniele; Decleva, Irene; Lupica, Loredana; Ghislanzoni, Massimo; Cusini, Marco; Alessi, Elvio.

In: Sexually Transmitted Diseases, Vol. 27, No. 4, 04.2000, p. 226-229.

Research output: Contribution to journalArticle

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