Mycosis fungoides in childhood: Description and study of two siblings

Camilla Vassallo, Valeria Brazzelli, Enza Cestone, Michela Castello, Olga Ciocca, Riccardo Giovanni Borroni, Miryam Martinetti, Giovanni Borroni

Research output: Contribution to journalArticle

Abstract

Primary cutaneous T-cell lymphomas are exceedingly rare in children and adolescents. However, mycosis fungoides (MF) is the most frequent primary cutaneous lymphoma diagnosed in childhood. Two cases of MF in siblings (a 14-year-old boy and his 10-year-old sister) are reported. On the basis of clinical features (histopathological and immunophenotypical findings) a diagnosis of MF patch lesions was made in both siblings. Since recent data in the literature have underlined a high frequency of the HLA-DQB1*03 allele in patients with familial MF (including child patients), the HLA profile of the patients was analysed, indicating the presence of a haplotype (HLA-DQB1*03,*03 in the girl, HLA-DQB1*02,*03 in the boy) corresponding with that described in recent literature. Two rare and exceptional cases of MF in siblings are reported, highlighting the presence of a peculiar haplotype.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalActa Dermato-Venereologica
Volume87
Issue number6
DOIs
Publication statusPublished - 2007

Fingerprint

Mycosis Fungoides
Siblings
childhood
Haplotypes
Cutaneous T-Cell Lymphoma
adolescent
Lymphoma
Alleles
Childhood
Boys
Skin
literature

Keywords

  • HLA
  • Mycosis fungoides
  • Sibling
  • UV-B-NB

ASJC Scopus subject areas

  • Dermatology

Cite this

Mycosis fungoides in childhood : Description and study of two siblings. / Vassallo, Camilla; Brazzelli, Valeria; Cestone, Enza; Castello, Michela; Ciocca, Olga; Borroni, Riccardo Giovanni; Martinetti, Miryam; Borroni, Giovanni.

In: Acta Dermato-Venereologica, Vol. 87, No. 6, 2007, p. 529-532.

Research output: Contribution to journalArticle

Vassallo, Camilla ; Brazzelli, Valeria ; Cestone, Enza ; Castello, Michela ; Ciocca, Olga ; Borroni, Riccardo Giovanni ; Martinetti, Miryam ; Borroni, Giovanni. / Mycosis fungoides in childhood : Description and study of two siblings. In: Acta Dermato-Venereologica. 2007 ; Vol. 87, No. 6. pp. 529-532.
@article{f1326e1f5e2a42749a3b2f35496d343d,
title = "Mycosis fungoides in childhood: Description and study of two siblings",
abstract = "Primary cutaneous T-cell lymphomas are exceedingly rare in children and adolescents. However, mycosis fungoides (MF) is the most frequent primary cutaneous lymphoma diagnosed in childhood. Two cases of MF in siblings (a 14-year-old boy and his 10-year-old sister) are reported. On the basis of clinical features (histopathological and immunophenotypical findings) a diagnosis of MF patch lesions was made in both siblings. Since recent data in the literature have underlined a high frequency of the HLA-DQB1*03 allele in patients with familial MF (including child patients), the HLA profile of the patients was analysed, indicating the presence of a haplotype (HLA-DQB1*03,*03 in the girl, HLA-DQB1*02,*03 in the boy) corresponding with that described in recent literature. Two rare and exceptional cases of MF in siblings are reported, highlighting the presence of a peculiar haplotype.",
keywords = "HLA, Mycosis fungoides, Sibling, UV-B-NB",
author = "Camilla Vassallo and Valeria Brazzelli and Enza Cestone and Michela Castello and Olga Ciocca and Borroni, {Riccardo Giovanni} and Miryam Martinetti and Giovanni Borroni",
year = "2007",
doi = "10.2340/00015555-0254",
language = "English",
volume = "87",
pages = "529--532",
journal = "Acta Borealia",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato-Venereologica",
number = "6",

}

TY - JOUR

T1 - Mycosis fungoides in childhood

T2 - Description and study of two siblings

AU - Vassallo, Camilla

AU - Brazzelli, Valeria

AU - Cestone, Enza

AU - Castello, Michela

AU - Ciocca, Olga

AU - Borroni, Riccardo Giovanni

AU - Martinetti, Miryam

AU - Borroni, Giovanni

PY - 2007

Y1 - 2007

N2 - Primary cutaneous T-cell lymphomas are exceedingly rare in children and adolescents. However, mycosis fungoides (MF) is the most frequent primary cutaneous lymphoma diagnosed in childhood. Two cases of MF in siblings (a 14-year-old boy and his 10-year-old sister) are reported. On the basis of clinical features (histopathological and immunophenotypical findings) a diagnosis of MF patch lesions was made in both siblings. Since recent data in the literature have underlined a high frequency of the HLA-DQB1*03 allele in patients with familial MF (including child patients), the HLA profile of the patients was analysed, indicating the presence of a haplotype (HLA-DQB1*03,*03 in the girl, HLA-DQB1*02,*03 in the boy) corresponding with that described in recent literature. Two rare and exceptional cases of MF in siblings are reported, highlighting the presence of a peculiar haplotype.

AB - Primary cutaneous T-cell lymphomas are exceedingly rare in children and adolescents. However, mycosis fungoides (MF) is the most frequent primary cutaneous lymphoma diagnosed in childhood. Two cases of MF in siblings (a 14-year-old boy and his 10-year-old sister) are reported. On the basis of clinical features (histopathological and immunophenotypical findings) a diagnosis of MF patch lesions was made in both siblings. Since recent data in the literature have underlined a high frequency of the HLA-DQB1*03 allele in patients with familial MF (including child patients), the HLA profile of the patients was analysed, indicating the presence of a haplotype (HLA-DQB1*03,*03 in the girl, HLA-DQB1*02,*03 in the boy) corresponding with that described in recent literature. Two rare and exceptional cases of MF in siblings are reported, highlighting the presence of a peculiar haplotype.

KW - HLA

KW - Mycosis fungoides

KW - Sibling

KW - UV-B-NB

UR - http://www.scopus.com/inward/record.url?scp=38849128948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38849128948&partnerID=8YFLogxK

U2 - 10.2340/00015555-0254

DO - 10.2340/00015555-0254

M3 - Article

C2 - 17989893

AN - SCOPUS:38849128948

VL - 87

SP - 529

EP - 532

JO - Acta Borealia

JF - Acta Borealia

SN - 0001-5555

IS - 6

ER -