Mycosis fungoides in childhood: Description and study of two siblings

Camilla Vassallo, Valeria Brazzelli, Enza Cestone, Michela Castello, Olga Ciocca, Riccardo Giovanni Borroni, Miryam Martinetti, Giovanni Borroni

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Primary cutaneous T-cell lymphomas are exceedingly rare in children and adolescents. However, mycosis fungoides (MF) is the most frequent primary cutaneous lymphoma diagnosed in childhood. Two cases of MF in siblings (a 14-year-old boy and his 10-year-old sister) are reported. On the basis of clinical features (histopathological and immunophenotypical findings) a diagnosis of MF patch lesions was made in both siblings. Since recent data in the literature have underlined a high frequency of the HLA-DQB1*03 allele in patients with familial MF (including child patients), the HLA profile of the patients was analysed, indicating the presence of a haplotype (HLA-DQB1*03,*03 in the girl, HLA-DQB1*02,*03 in the boy) corresponding with that described in recent literature. Two rare and exceptional cases of MF in siblings are reported, highlighting the presence of a peculiar haplotype.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalActa Dermato-Venereologica
Issue number6
Publication statusPublished - 2007


  • HLA
  • Mycosis fungoides
  • Sibling
  • UV-B-NB

ASJC Scopus subject areas

  • Dermatology


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