Mycosis fungoides in patients under 20 years of age: Report of 7 cases, review of the literature and study of the clinical course

P. Quaglino, A. Zaccagna, A. Verrone, F. Dardano, Maria Grazia Bernengo

Research output: Contribution to journalArticle

Abstract

Background: Mycosis fungoides (MF) is rare in young patients. Its clinical behavior is still uncertain, as some reports have suggested that it has a more aggressive course than does the adult-onset type. Aim: To ascertain if early-onset MF represents a heterogeneous group of cutaneous T cell lymphomas. Materials and Methods: Clinical, immunohistopathological and follow-up data of early-onset (<20 years of age) MF cases reported in the literature (n = 42) plus 7 described herein were compared with those of a cohort of adult-onset MF patients (n = 252) diagnosed at our institution since 1975. Results: The majority of the 49 early-onset MF patients had patch-plaque stage disease at diagnosis. Ten had hypopigmented lesions. The predominant phenotype was CD3+CD4+CD7-CD8-. Seven patients had a stage progression, 6 with extracutaneous involvement. Five- and 10-year survival rates were 93 and 74%, respectively. Conclusions: No statistically significant differences were found in the disease course between early- and adult-onset MF.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalDermatology
Volume199
Issue number1
DOIs
Publication statusPublished - 1999

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Mycosis Fungoides
Cutaneous T-Cell Lymphoma
Clinical Studies
Survival Rate
Phenotype

Keywords

  • Adolescence
  • Age factors
  • Childhood
  • Immunophenotyping
  • Mycosis fungoides
  • Mycosis fungoides prognosis
  • Mycosis fungoides survival

ASJC Scopus subject areas

  • Dermatology

Cite this

Mycosis fungoides in patients under 20 years of age : Report of 7 cases, review of the literature and study of the clinical course. / Quaglino, P.; Zaccagna, A.; Verrone, A.; Dardano, F.; Bernengo, Maria Grazia.

In: Dermatology, Vol. 199, No. 1, 1999, p. 8-14.

Research output: Contribution to journalArticle

Quaglino, P. ; Zaccagna, A. ; Verrone, A. ; Dardano, F. ; Bernengo, Maria Grazia. / Mycosis fungoides in patients under 20 years of age : Report of 7 cases, review of the literature and study of the clinical course. In: Dermatology. 1999 ; Vol. 199, No. 1. pp. 8-14.
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