Abstract
The mydriatic effect of three ocular decongestants, containing 0.1% tetrahydrozoline hydrochloride, 0.3% chlorpheniramine maleate, and 0.05% tetrahydrozoline hydrochloride in combination with 0.3% pheniramine maleate, respectively, was evaluated in 10 healthy volunteers. The study was carried out using a single dose of the tested drug, instilling 2 drops in one eye and 2 drops of a placebo in the other. The pupillary diameters were measured by photographic pupillography under basal conditions and 15, 30, 45, 60, 90, and 120 min after each treatment. Near and distance visual acuity and tonometry were evaluated under basal conditions and 50 and 95 min after instillation of drugs. No statistical significant differences between the treated and the control pupil diameters were found after instillation of 0.1% tetrahydrozoline hydrochloride or 0.3% chlorpheniramine maleate. The combination of 0.05% tetrahydrozoline hydrochloride with 0.3% pheniramine maleate caused a significant mydriasis from 30 min up to 120 min (p
| Original language | English |
|---|---|
| Pages (from-to) | 243-246 |
| Number of pages | 4 |
| Journal | Ophthalmologica |
| Volume | 208 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1994 |
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Keywords
- Decongestant
- Decongestant eyedrops
- Mydriatic effect
- Pupillography
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
Cite this
Mydriatic effect of ocular decongestants studied by pupillography. / Gelmi, Carlo; Ceccuzzi, R.
In: Ophthalmologica, Vol. 208, No. 5, 1994, p. 243-246.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mydriatic effect of ocular decongestants studied by pupillography
AU - Gelmi, Carlo
AU - Ceccuzzi, R.
PY - 1994
Y1 - 1994
N2 - The mydriatic effect of three ocular decongestants, containing 0.1% tetrahydrozoline hydrochloride, 0.3% chlorpheniramine maleate, and 0.05% tetrahydrozoline hydrochloride in combination with 0.3% pheniramine maleate, respectively, was evaluated in 10 healthy volunteers. The study was carried out using a single dose of the tested drug, instilling 2 drops in one eye and 2 drops of a placebo in the other. The pupillary diameters were measured by photographic pupillography under basal conditions and 15, 30, 45, 60, 90, and 120 min after each treatment. Near and distance visual acuity and tonometry were evaluated under basal conditions and 50 and 95 min after instillation of drugs. No statistical significant differences between the treated and the control pupil diameters were found after instillation of 0.1% tetrahydrozoline hydrochloride or 0.3% chlorpheniramine maleate. The combination of 0.05% tetrahydrozoline hydrochloride with 0.3% pheniramine maleate caused a significant mydriasis from 30 min up to 120 min (p
AB - The mydriatic effect of three ocular decongestants, containing 0.1% tetrahydrozoline hydrochloride, 0.3% chlorpheniramine maleate, and 0.05% tetrahydrozoline hydrochloride in combination with 0.3% pheniramine maleate, respectively, was evaluated in 10 healthy volunteers. The study was carried out using a single dose of the tested drug, instilling 2 drops in one eye and 2 drops of a placebo in the other. The pupillary diameters were measured by photographic pupillography under basal conditions and 15, 30, 45, 60, 90, and 120 min after each treatment. Near and distance visual acuity and tonometry were evaluated under basal conditions and 50 and 95 min after instillation of drugs. No statistical significant differences between the treated and the control pupil diameters were found after instillation of 0.1% tetrahydrozoline hydrochloride or 0.3% chlorpheniramine maleate. The combination of 0.05% tetrahydrozoline hydrochloride with 0.3% pheniramine maleate caused a significant mydriasis from 30 min up to 120 min (p
KW - Decongestant
KW - Decongestant eyedrops
KW - Mydriatic effect
KW - Pupillography
UR - http://www.scopus.com/inward/record.url?scp=0028024356&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028024356&partnerID=8YFLogxK
U2 - 10.1159/000310499
DO - 10.1159/000310499
M3 - Article
C2 - 7816414
AN - SCOPUS:0028024356
VL - 208
SP - 243
EP - 246
JO - Ophthalmologica
JF - Ophthalmologica
SN - 0030-3755
IS - 5
ER -