Mydriatic effect of ocular decongestants studied by pupillography

Carlo Gelmi, R. Ceccuzzi

Research output: Contribution to journalArticlepeer-review


The mydriatic effect of three ocular decongestants, containing 0.1% tetrahydrozoline hydrochloride, 0.3% chlorpheniramine maleate, and 0.05% tetrahydrozoline hydrochloride in combination with 0.3% pheniramine maleate, respectively, was evaluated in 10 healthy volunteers. The study was carried out using a single dose of the tested drug, instilling 2 drops in one eye and 2 drops of a placebo in the other. The pupillary diameters were measured by photographic pupillography under basal conditions and 15, 30, 45, 60, 90, and 120 min after each treatment. Near and distance visual acuity and tonometry were evaluated under basal conditions and 50 and 95 min after instillation of drugs. No statistical significant differences between the treated and the control pupil diameters were found after instillation of 0.1% tetrahydrozoline hydrochloride or 0.3% chlorpheniramine maleate. The combination of 0.05% tetrahydrozoline hydrochloride with 0.3% pheniramine maleate caused a significant mydriasis from 30 min up to 120 min (p

Original languageEnglish
Pages (from-to)243-246
Number of pages4
Issue number5
Publication statusPublished - 1994


  • Decongestant
  • Decongestant eyedrops
  • Mydriatic effect
  • Pupillography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems


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