Myelin basic protein-specific T lymphocytes proliferation and programmed cell death in demyelinating diseases

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Abstract

A dynamic equilibrium between proliferation and programmed cell death (PCD) of auto-reactive T lymphocytes plays a pivotal role in the prevention of autoimmune diseases. We analyzed T lymphocytes myelin basic protein (MBP)-specific PCD and proliferation in demyelinating diseases. Results showed that MBP-specific PCD was significantly decreased in CD4+ and CD8+ T lymphocytes of progressive multifocal leukoencephalopathy (PML), not determined leukoencephalopathy (NDLE), and acute MS (AMS) patients compared to patients with stable MS (SMS) and healthy controls. MBP-specific proliferation/PCD rates were high in CD4+ T lymphocytes of PML, NDLE, and AMS patients, and in CD8+ T cells of PML and AMS individuals alone. Alterations of the balance between MBP-specific proliferation and PCD are present in demyelinating diseases and could play a major role in the pathogenesis of these diseases.

Original languageEnglish
Pages (from-to)509-517
Number of pages9
JournalClinical Immunology
Volume129
Issue number3
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Apoptosis
  • Demyelinating diseases
  • Multiple sclerosis
  • Myelin basic protein
  • PCD

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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