Myelination in bipolar patients and the effects of mood stabilizers on brain anatomy

Paolo Brambilla, Marcella Bellani, Ping Hong Yeh, Jair C. Soares

Research output: Contribution to journalArticle

Abstract

In this review, we debate the evidence for abnormal white matter microstructure and myelination in bipolar disorder, as mainly detected by diffusion tensor imaging (DTI) studies. The effects of mood stabilizers on white matter are discussed, based on available findings from human and animal studies. Last, perspectives in this field of research are also drawn.

Original languageEnglish
Pages (from-to)2632-2636
Number of pages5
JournalCurrent Pharmaceutical Design
Volume15
Issue number22
DOIs
Publication statusPublished - 2009

Keywords

  • Amygdala
  • Corpus callosum
  • Diffusion imaging
  • Hippocampus
  • Lithium
  • Prefrontal cortex
  • Valproate
  • White matter

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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