Myelofibrosis with myeloid metaplasia: Clinical and haematological parameters predicting survival in a series of 133 patients

G. Visani, C. Finelli, U. Castelli, M. C. Petti, P. Ricci, N. Vianelli, L. Gianni, E. Zuffa, M. A. Aloe Spiriti, R. Latagliata, S. Pileri, U. Magrini, L. Gugliotta, E. Morra, C. Bernasconi, F. Mandelli, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic value of 12 clinical and haematological parameters, recorded at diagnosis, in myelofibrosis wiht myeloid metaplasia (MMM) was retrospectively analysed in a consecutive series of 133 patients followed for a minimum of 60 months. Multivariate analysis showed that the following features were associated with a significantly shorter survival: (1) short period of time (12 x 109/l; (4) peripheral blood granulocyte precursors >10%. Age, splenectomy and percentage of peripheral blood metamyelocytes were found significantly to affect survival only from univariate analysis, whereas sex, size of spleen, thrombocytopenia and thrombocytosis were of no prognostic significance. These data suggest that a more intensive chemotherapy might be useful for younger patients with bad prognostic factors at diagnosis.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalBritish Journal of Haematology
Volume75
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Hematology

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