Myelofibrosis with myeloid metaplasia in young individuals: Disease characteristics, prognostic factors and identification of risk groups

Francisco Cervantes, Giovanni Barosi, Jean Loup Demory, John Reilly, Roberta Guarnone, Brigitte Dupriez, Arturo Pereira, Emilio Montserrat

Research output: Contribution to journalArticle

Abstract

Myelofibrosis with myeloid metaplasia (MMM) is an uncommon disorder in young individuals, for whom haemopoietic stem cell transplantation offers the only possibility of cure. However, although the latter procedure is associated with significant morbidity and mortality, the clinical course of MMM is variable with some patients surviving for less than a year and others showing an indolent course. Selection of young MMM patients for transplantation or other newer therapies is currently difficult since no prognostic data exists for this subgroup. In the present collaborative study a number of initial clinical and laboratory parameters have been evaluated for prognosis in 121 MMM patients aged 55 years or less. Median survival of the series was 128 months (95% CI 90172). In the Cox proportional hazard regression model three initial variables were independently associated with shorter survival: Hb

Original languageEnglish
Pages (from-to)684-690
Number of pages7
JournalBritish Journal of Haematology
Volume102
Issue number3
DOIs
Publication statusPublished - 1998

Keywords

  • Myelofibrosis with myeloid metaplasia
  • Prognosis
  • Young patients

ASJC Scopus subject areas

  • Hematology

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