Myeloid Cells and Chronic Liver Disease: a Comprehensive Review

Min Lian, Carlo Selmi, M Eric Gershwin, Xiong Ma

Research output: Contribution to journalReview article

Abstract

Myeloid cells play a major role in the sensitization to liver injury, particularly in chronic inflammatory liver diseases with a biliary or hepatocellular origin, and the interplay between myeloid cells and the liver may explain the increased incidence of hepatic osteodystrophy. The myeloid cell-liver axis involves several mature myeloid cells as well as immature or progenitor cells with the complexity of the liver immune microenvironment aggravating the mist of cell differentiation. The unique positioning of the liver at the junction of the peripheral and portal circulation systems underlines the interaction of myeloid cells and hepatic cells and leads to immune tolerance breakdown. We herein discuss the scenarios of different chronic liver diseases closely modulated by myeloid cells and illustrate the numerous potential targets, the understanding of which will ultimately steer the development of solid immunotherapeutic regimens. Ultimately, we are convinced that an adequate modulation of the liver microenvironment to modify the functional and quantitative characteristics of myeloid cells will be a successful approach to treating chronic liver diseases of different etiologies.

Original languageEnglish
Pages (from-to)307-317
Number of pages11
JournalClinical Reviews in Allergy and Immunology
Volume54
Issue number2
DOIs
Publication statusPublished - Apr 2018

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Keywords

  • Animals
  • Cell Differentiation
  • Chronic Disease
  • Hepatocytes/immunology
  • Humans
  • Immune Tolerance
  • Immunomodulation
  • Liver/immunology
  • Liver Diseases/immunology
  • Myeloid Cells/immunology

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