Abstract
Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines.
Original language | English |
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Pages (from-to) | 249-253 |
Number of pages | 5 |
Journal | Immunobiology |
Volume | 220 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Cancer-related inflammation
- Chemokine
- Myeloid cells
- Myeloid-derived suppressor cells
- Tumor-associated macrophages
- Tumor-associated neutrophils
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Hematology
- Medicine(all)