Myeloid cells in cancer-related inflammation

Nicoletta Caronni, Benedetta Savino, Raffaella Bonecchi

Research output: Contribution to journalArticlepeer-review

Abstract

Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalImmunobiology
Volume220
Issue number2
DOIs
Publication statusPublished - 2015

Keywords

  • Cancer-related inflammation
  • Chemokine
  • Myeloid cells
  • Myeloid-derived suppressor cells
  • Tumor-associated macrophages
  • Tumor-associated neutrophils

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Medicine(all)

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