Myeloid-derived suppressor cell heterogeneity in human cancers

Samantha Solito, Ilaria Marigo, Laura Pinton, Vera Damuzzo, Susanna Mandruzzato, Vincenzo Bronte

Research output: Contribution to journalArticlepeer-review

Abstract

The dynamic interplay between cancer and host immune system often affects the process of myelopoiesis. As a consequence, tumor-derived factors sustain the accumulation and functional differentiation of myeloid cells, including myeloid-derived suppressor cells (MDSCs), which can interfere with T cell-mediated responses. Since both the phenotype and mechanisms of action of MDSCs appear to be tumor-dependent, it is important not only to determine the presence of all MDSC subsets in each cancer patient, but also which MDSC subsets have clinical relevance in each tumor environment. In this review, we describe the differences between MDSC populations expanded within different tumor contexts and evaluate the prognostic significance of MDSC expansion in peripheral blood and within tumor masses of neoplastic patients.

Original languageEnglish
Pages (from-to)47-65
Number of pages19
JournalAnnals of the New York Academy of Sciences
Volume1319
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Cancer
  • Immunosuppression
  • Innate immunity
  • MDSCs
  • Myeloid-derived suppressor cells
  • T cells
  • Tumors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'Myeloid-derived suppressor cell heterogeneity in human cancers'. Together they form a unique fingerprint.

Cite this