Myeloid-derived suppressor cell role in tumor-related inflammation

Luigi Dolcetti; Ilaria Marigo; Barbara Mantelli; Elisa Peranzoni; Paola Zanovello; Vincenzo Bronte

doi:10.1016/j.canlet.2008.03.012

Myeloid-derived suppressor cell role in tumor-related inflammation

Luigi Dolcetti, Ilaria Marigo, Barbara Mantelli, Elisa Peranzoni, Paola Zanovello, Vincenzo Bronte

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Chronic inflammatory state can create a proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression, respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy.

Original language	English
Pages (from-to)	216-225
Number of pages	10
Journal	Cancer Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.03.012
Publication status	Published - Aug 28 2008

Keywords

Arginine metabolism
Cancer
Immune suppression
Inflammation
MDSC
Myeloid cells
NO

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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AU - Dolcetti, Luigi

AU - Marigo, Ilaria

AU - Mantelli, Barbara

AU - Peranzoni, Elisa

AU - Zanovello, Paola

AU - Bronte, Vincenzo

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Chronic inflammatory state can create a proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression, respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy.

AB - Chronic inflammatory state can create a proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression, respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy.

KW - Arginine metabolism

KW - Cancer

KW - Immune suppression

KW - Inflammation

KW - MDSC

KW - Myeloid cells

KW - NO

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Myeloid-derived suppressor cell role in tumor-related inflammation

Abstract

Keywords

ASJC Scopus subject areas

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