Myeloid-derived suppressor cell role in tumor-related inflammation

Luigi Dolcetti, Ilaria Marigo, Barbara Mantelli, Elisa Peranzoni, Paola Zanovello, Vincenzo Bronte

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic inflammatory state can create a proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression, respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalCancer Letters
Volume267
Issue number2
DOIs
Publication statusPublished - Aug 28 2008

Keywords

  • Arginine metabolism
  • Cancer
  • Immune suppression
  • Inflammation
  • MDSC
  • Myeloid cells
  • NO

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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