Abstract
Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensively investigated in preclinical models, especially in the context of cancer. One of the major obstacles in their accurate identification has been the definition of an unambiguous phenotype, shared between mice and humans, and clearly correlating with their suppressive function. In this paper, we review the literature concerning the phenotype in mouse and in humans, showing that at least 2 subsets of MDSCs are present under different situations. We also address the role of MDSCs in tumor progression, evaluate the prognostic significance of MDSC in cancer patients, and their possible role as marker of clinical outcome and response to therapy. Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 107-115 |
| Number of pages | 9 |
| Journal | Journal of Immunotherapy |
| Volume | 35 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- myeloid cells
- myeloid-derived suppressor cells
- suppression
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Cancer Research
- Pharmacology
Cite this
Myeloid-derived suppressor cells in cancer patients : A clinical perspective. / Montero, Alberto J.; Diaz-Montero, Claudia Marcela; Kyriakopoulos, Christos E.; Bronte, Vincenzo; Mandruzzato, Susanna.
In: Journal of Immunotherapy, Vol. 35, No. 2, 02.2012, p. 107-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myeloid-derived suppressor cells in cancer patients
T2 - A clinical perspective
AU - Montero, Alberto J.
AU - Diaz-Montero, Claudia Marcela
AU - Kyriakopoulos, Christos E.
AU - Bronte, Vincenzo
AU - Mandruzzato, Susanna
PY - 2012/2
Y1 - 2012/2
N2 - Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensively investigated in preclinical models, especially in the context of cancer. One of the major obstacles in their accurate identification has been the definition of an unambiguous phenotype, shared between mice and humans, and clearly correlating with their suppressive function. In this paper, we review the literature concerning the phenotype in mouse and in humans, showing that at least 2 subsets of MDSCs are present under different situations. We also address the role of MDSCs in tumor progression, evaluate the prognostic significance of MDSC in cancer patients, and their possible role as marker of clinical outcome and response to therapy. Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies.
AB - Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensively investigated in preclinical models, especially in the context of cancer. One of the major obstacles in their accurate identification has been the definition of an unambiguous phenotype, shared between mice and humans, and clearly correlating with their suppressive function. In this paper, we review the literature concerning the phenotype in mouse and in humans, showing that at least 2 subsets of MDSCs are present under different situations. We also address the role of MDSCs in tumor progression, evaluate the prognostic significance of MDSC in cancer patients, and their possible role as marker of clinical outcome and response to therapy. Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies.
KW - myeloid cells
KW - myeloid-derived suppressor cells
KW - suppression
UR - http://www.scopus.com/inward/record.url?scp=84856899903&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856899903&partnerID=8YFLogxK
U2 - 10.1097/CJI.0b013e318242169f
DO - 10.1097/CJI.0b013e318242169f
M3 - Article
VL - 35
SP - 107
EP - 115
JO - Journal of Immunotherapy
JF - Journal of Immunotherapy
SN - 1053-8550
IS - 2
ER -