Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy

Stefano A. Pileri, Fabio Facchetti, Stefano Ascani, Elena Sabattini, Simonetta Poggi, Milena Piccioli, Damiano Rondelli, Federica Vergoni, Pier Luigi Zinzani, Pier Paolo Piccaluga, Brunangelo Falini, Peter G. Isaacson

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Forty-five examples of Kikuchi's lymphadenitis (KL), 5 Kikuchi-like lupus erythematosus lymphadenopathies, 25 nonnecrotizing lymphadenitidies (5 toxoplasmic, 5 sarcoid-like, 6 dermatopathic, 4 suppurative, 3 tubercular, 2 with sinus histiocytosis), 4 examples of hyaline-vascular Castleman disease (CD), 2 plasmacytoid monocyte tumors (PM-Ts), and 61 accessory cell neoplasms were studied by a panel of antibodies, including the PG-M1 (against a macrophage-restricted CD68 epitope) and a polyclonal antimyeloperoxidase (MPO). In KL and Kikuchi-like lupus erythematosus lymphadenopathies, 25 to 75% of CD68+ histiocytes co-expressed MPO. This did not occur in nonnecrotizing lymphadenitidies and accessory cell neoplasms. MPO+/CD68+ elements corresponded to nonphagocytosing mononuclear cells and some crescentic macrophages and phagocytosing histiocytes. Typical PMs were MPO-/CD68+ in all cases, including CD and PM-T. Our observations suggest that in KL and KL-like lymphadenopathies: 1) MPO+/ CD68+ blood monocytes might be attracted into tissues because of the lack or paucity of granulocytes and the need of MPO for oxidative processes; 2) PMs are more likely to be involved in the cytotoxic immune reaction than in phagocytic phenomena; 3) the peculiar phenotype of the histiocytic component can be usefully used for the differentiation from malignant lymphoma and PM-T.

Original languageEnglish
Pages (from-to)915-924
Number of pages10
JournalAmerican Journal of Pathology
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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