Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy

Stefano A. Pileri, Fabio Facchetti, Stefano Ascani, Elena Sabattini, Simonetta Poggi, Milena Piccioli, Damiano Rondelli, Federica Vergoni, Pier Luigi Zinzani, Pier Paolo Piccaluga, Brunangelo Falini, Peter G. Isaacson

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Abstract

Forty-five examples of Kikuchi's lymphadenitis (KL), 5 Kikuchi-like lupus erythematosus lymphadenopathies, 25 nonnecrotizing lymphadenitidies (5 toxoplasmic, 5 sarcoid-like, 6 dermatopathic, 4 suppurative, 3 tubercular, 2 with sinus histiocytosis), 4 examples of hyaline-vascular Castleman disease (CD), 2 plasmacytoid monocyte tumors (PM-Ts), and 61 accessory cell neoplasms were studied by a panel of antibodies, including the PG-M1 (against a macrophage-restricted CD68 epitope) and a polyclonal antimyeloperoxidase (MPO). In KL and Kikuchi-like lupus erythematosus lymphadenopathies, 25 to 75% of CD68+ histiocytes co-expressed MPO. This did not occur in nonnecrotizing lymphadenitidies and accessory cell neoplasms. MPO+/CD68+ elements corresponded to nonphagocytosing mononuclear cells and some crescentic macrophages and phagocytosing histiocytes. Typical PMs were MPO-/CD68+ in all cases, including CD and PM-T. Our observations suggest that in KL and KL-like lymphadenopathies: 1) MPO+/ CD68+ blood monocytes might be attracted into tissues because of the lack or paucity of granulocytes and the need of MPO for oxidative processes; 2) PMs are more likely to be involved in the cytotoxic immune reaction than in phagocytic phenomena; 3) the peculiar phenotype of the histiocytic component can be usefully used for the differentiation from malignant lymphoma and PM-T.

Original languageEnglish
Pages (from-to)915-924
Number of pages10
JournalAmerican Journal of Pathology
Volume159
Issue number3
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pileri, S. A., Facchetti, F., Ascani, S., Sabattini, E., Poggi, S., Piccioli, M., Rondelli, D., Vergoni, F., Zinzani, P. L., Piccaluga, P. P., Falini, B., & Isaacson, P. G. (2001). Myeloperoxidase expression by histiocytes in Kikuchi's and Kikuchi-like lymphadenopathy. American Journal of Pathology, 159(3), 915-924.