Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters

Aderville Cabassi, Simone Maurizio Binno, Stefano Tedeschi, Gallia Graiani, Cinzia Galizia, Michele Bianconcini, Pietro Coghi, Federica Fellini, Livia Ruffini, Paolo Govoni, Massimo Piepoli, Stefano Perlini, Giuseppe Regolisti, Enrico Fiaccadori

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Rationale. Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions. Objective. We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients. Methods and Results. In chronic HF patients (n = 81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n = 17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured. Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR. FeOxI, albumin, and prealbumin were decreased in HF. MPO-related chlorinating activity was positively related to Cp (r = 0.363, P <0.001), nitrated protein, hsCRP, and BNP and inversely to albumin. Conclusions. Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.

Original languageEnglish
Article number691693
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Ceruloplasmin
Chlorination
Halogenation
Peroxidase
Heart Failure
Nitration
Plasmas
Albumins
Prealbumin
Norepinephrine
Proteins
Biomarkers
Malondialdehyde
Free Radicals
Tyrosine
Nitric Oxide
Oxidative Stress
Antioxidants
Oxygen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients : Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters. / Cabassi, Aderville; Binno, Simone Maurizio; Tedeschi, Stefano; Graiani, Gallia; Galizia, Cinzia; Bianconcini, Michele; Coghi, Pietro; Fellini, Federica; Ruffini, Livia; Govoni, Paolo; Piepoli, Massimo; Perlini, Stefano; Regolisti, Giuseppe; Fiaccadori, Enrico.

In: BioMed Research International, Vol. 2015, 691693, 2015.

Research output: Contribution to journalArticle

Cabassi, A, Binno, SM, Tedeschi, S, Graiani, G, Galizia, C, Bianconcini, M, Coghi, P, Fellini, F, Ruffini, L, Govoni, P, Piepoli, M, Perlini, S, Regolisti, G & Fiaccadori, E 2015, 'Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters', BioMed Research International, vol. 2015, 691693. https://doi.org/10.1155/2015/691693
Cabassi, Aderville ; Binno, Simone Maurizio ; Tedeschi, Stefano ; Graiani, Gallia ; Galizia, Cinzia ; Bianconcini, Michele ; Coghi, Pietro ; Fellini, Federica ; Ruffini, Livia ; Govoni, Paolo ; Piepoli, Massimo ; Perlini, Stefano ; Regolisti, Giuseppe ; Fiaccadori, Enrico. / Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients : Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters. In: BioMed Research International. 2015 ; Vol. 2015.
@article{75cd2a860e3445dfae4983d9d4eecb52,
title = "Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients: Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters",
abstract = "Rationale. Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions. Objective. We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients. Methods and Results. In chronic HF patients (n = 81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n = 17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured. Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR. FeOxI, albumin, and prealbumin were decreased in HF. MPO-related chlorinating activity was positively related to Cp (r = 0.363, P <0.001), nitrated protein, hsCRP, and BNP and inversely to albumin. Conclusions. Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.",
author = "Aderville Cabassi and Binno, {Simone Maurizio} and Stefano Tedeschi and Gallia Graiani and Cinzia Galizia and Michele Bianconcini and Pietro Coghi and Federica Fellini and Livia Ruffini and Paolo Govoni and Massimo Piepoli and Stefano Perlini and Giuseppe Regolisti and Enrico Fiaccadori",
year = "2015",
doi = "10.1155/2015/691693",
language = "English",
volume = "2015",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Myeloperoxidase-Related Chlorination Activity Is Positively Associated with Circulating Ceruloplasmin in Chronic Heart Failure Patients

T2 - Relationship with Neurohormonal, Inflammatory, and Nutritional Parameters

AU - Cabassi, Aderville

AU - Binno, Simone Maurizio

AU - Tedeschi, Stefano

AU - Graiani, Gallia

AU - Galizia, Cinzia

AU - Bianconcini, Michele

AU - Coghi, Pietro

AU - Fellini, Federica

AU - Ruffini, Livia

AU - Govoni, Paolo

AU - Piepoli, Massimo

AU - Perlini, Stefano

AU - Regolisti, Giuseppe

AU - Fiaccadori, Enrico

PY - 2015

Y1 - 2015

N2 - Rationale. Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions. Objective. We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients. Methods and Results. In chronic HF patients (n = 81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n = 17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured. Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR. FeOxI, albumin, and prealbumin were decreased in HF. MPO-related chlorinating activity was positively related to Cp (r = 0.363, P <0.001), nitrated protein, hsCRP, and BNP and inversely to albumin. Conclusions. Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.

AB - Rationale. Heart failure (HF) is accompanied by the development of an imbalance between oxygen- and nitric oxide-derived free radical production leading to protein nitration. Both chlorinating and peroxidase cycle of Myeloperoxidase (MPO) contribute to oxidative and nitrosative stress and are involved in tyrosine nitration of protein. Ceruloplasmin (Cp) has antioxidant function through its ferroxidase I (FeOxI) activity and has recently been proposed as a physiological defense mechanism against MPO inappropriate actions. Objective. We investigated the relationship between plasma MPO-related chlorinating activity, Cp and FeOxI, and nitrosative stress, inflammatory, neurohormonal, and nutritional biomarkers in HF patients. Methods and Results. In chronic HF patients (n = 81, 76 ± 9 years, NYHA Class II (26); Class III (29); Class IV (26)) and age-matched controls (n = 17, 75 ± 11 years, CTR), plasma MPO chlorinating activity, Cp, FeOxI, nitrated protein, free Malondialdehyde, BNP, norepinephrine, hsCRP, albumin, and prealbumin were measured. Plasma MPO chlorinating activity, Cp, BNP, norepinephrine, and hsCRP were increased in HF versus CTR. FeOxI, albumin, and prealbumin were decreased in HF. MPO-related chlorinating activity was positively related to Cp (r = 0.363, P <0.001), nitrated protein, hsCRP, and BNP and inversely to albumin. Conclusions. Plasma MPO chlorinated activity is increased in elderly chronic HF patients and positively associated with Cp, inflammatory, neurohormonal, and nitrosative parameters suggesting a role in HF progression.

UR - http://www.scopus.com/inward/record.url?scp=84945962267&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84945962267&partnerID=8YFLogxK

U2 - 10.1155/2015/691693

DO - 10.1155/2015/691693

M3 - Article

AN - SCOPUS:84945962267

VL - 2015

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 691693

ER -