Abstract
Objective - To assess the relation between left ventricular function and myocardial β adrenoceptor density. Methods - 17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial β adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls. Results - Myocardial β adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P <0.01). β Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P <0.05), and there was a significant correlation (r = 0.52; P <0.05) between left ventricular fractional shortening and myocardial β adrenoceptor density. A positive correlation (r = 0.51; P <0.05) was also found between myocardial β adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function. Conclusions - There is myocardial β adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.
| Original language | English |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Heart |
| Volume | 75 |
| Issue number | 1 |
| Publication status | Published - 1996 |
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Keywords
- Hypertrophic cardiomyopathy
- Left ventricular function
- Myocardial adrenoceptors
- Positron emission tomography
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy. / Choudhury, Lubna; Guzzetti, Stefano; Lefroy, David C.; Nihoyannopoulos, Petros; McKenna, William J.; Oakley, Celia M.; Camici, Paolo G.
In: Heart, Vol. 75, No. 1, 1996, p. 50-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy
AU - Choudhury, Lubna
AU - Guzzetti, Stefano
AU - Lefroy, David C.
AU - Nihoyannopoulos, Petros
AU - McKenna, William J.
AU - Oakley, Celia M.
AU - Camici, Paolo G.
PY - 1996
Y1 - 1996
N2 - Objective - To assess the relation between left ventricular function and myocardial β adrenoceptor density. Methods - 17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial β adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls. Results - Myocardial β adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P <0.01). β Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P <0.05), and there was a significant correlation (r = 0.52; P <0.05) between left ventricular fractional shortening and myocardial β adrenoceptor density. A positive correlation (r = 0.51; P <0.05) was also found between myocardial β adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function. Conclusions - There is myocardial β adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.
AB - Objective - To assess the relation between left ventricular function and myocardial β adrenoceptor density. Methods - 17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial β adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls. Results - Myocardial β adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P <0.01). β Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P <0.05), and there was a significant correlation (r = 0.52; P <0.05) between left ventricular fractional shortening and myocardial β adrenoceptor density. A positive correlation (r = 0.51; P <0.05) was also found between myocardial β adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function. Conclusions - There is myocardial β adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.
KW - Hypertrophic cardiomyopathy
KW - Left ventricular function
KW - Myocardial adrenoceptors
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=0030025184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030025184&partnerID=8YFLogxK
M3 - Article
VL - 75
SP - 50
EP - 54
JO - Heart
JF - Heart
SN - 1355-6037
IS - 1
ER -