Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy

Lubna Choudhury, Stefano Guzzetti, David C. Lefroy, Petros Nihoyannopoulos, William J. McKenna, Celia M. Oakley, Paolo G. Camici

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective - To assess the relation between left ventricular function and myocardial β adrenoceptor density. Methods - 17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial β adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls. Results - Myocardial β adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P <0.01). β Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P <0.05), and there was a significant correlation (r = 0.52; P <0.05) between left ventricular fractional shortening and myocardial β adrenoceptor density. A positive correlation (r = 0.51; P <0.05) was also found between myocardial β adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function. Conclusions - There is myocardial β adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalHeart
Volume75
Issue number1
Publication statusPublished - 1996

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Hypertrophic Cardiomyopathy
Left Ventricular Function
Adrenergic Receptors
Heart Failure
Ventricular Function
Positron-Emission Tomography
Echocardiography
Down-Regulation

Keywords

  • Hypertrophic cardiomyopathy
  • Left ventricular function
  • Myocardial adrenoceptors
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Choudhury, L., Guzzetti, S., Lefroy, D. C., Nihoyannopoulos, P., McKenna, W. J., Oakley, C. M., & Camici, P. G. (1996). Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy. Heart, 75(1), 50-54.

Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy. / Choudhury, Lubna; Guzzetti, Stefano; Lefroy, David C.; Nihoyannopoulos, Petros; McKenna, William J.; Oakley, Celia M.; Camici, Paolo G.

In: Heart, Vol. 75, No. 1, 1996, p. 50-54.

Research output: Contribution to journalArticle

Choudhury, L, Guzzetti, S, Lefroy, DC, Nihoyannopoulos, P, McKenna, WJ, Oakley, CM & Camici, PG 1996, 'Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy', Heart, vol. 75, no. 1, pp. 50-54.
Choudhury L, Guzzetti S, Lefroy DC, Nihoyannopoulos P, McKenna WJ, Oakley CM et al. Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy. Heart. 1996;75(1):50-54.
Choudhury, Lubna ; Guzzetti, Stefano ; Lefroy, David C. ; Nihoyannopoulos, Petros ; McKenna, William J. ; Oakley, Celia M. ; Camici, Paolo G. / Myocardial β adrenoceptors and left ventricular function in hypertrophic cardiomyopathy. In: Heart. 1996 ; Vol. 75, No. 1. pp. 50-54.
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