Regional myocardial perfusion and glucose uptake were assessed with rubidium 82 (Rb), F-18-deoxyglucose (FDG) and positron emission tomography (PET) in patients with coronary artery disease and stable (SA) or unstable (UA) angina pectoris and in a group of normal subjects. In SA patients at rest, myocardial perfusion and glucose uptake were comparable to those in normal subjects. However, a regionally increased FDG uptake was observed in the SA patients during recovery from an episode of exercise-induced ischaemia, in the same regions that showed abnormal perfusion during the stress test. In UA patients, regional myocardial perfusion at rest was not significantly different from that in SA patients and normal subjects. Conversely, in all UA patients myocardial glucose utilization was significantly greater than in SA patients and normal subjects. This occurred in the absence of symptoms and electrocardiographic signs of acute ischaemia at the time of the study. A significant reduction of myocardial glucose utilization - which, however, remained higher than in SA patients and normal subjects - was observed in the UA patients who were restudied during i.v. infusion of nitrates.
- Myocardial ischemia
- Myocardial metabolism
- Positron emission tomography
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging