Myocardial damage due to hypokalaemia and hypophosphataemia

A. Frustaci, F. Pennestri, C. Scoppetta

Research output: Contribution to journalArticlepeer-review


A case of severe hypokalaemia with stupor, skeletal muscle and heart muscle damage is reported. An initial infusion of glucose-insulin and potassium (GIK) produced a temporary clinical improvement with reduction of creatine kinase (CKMB) and elevation of serum K+. On the 4th day of treatment, neuromuscular and cardiovascular deterioration occurred accompanied by a further rise of CKMB. This deterioration was coincident with a serum phosphate of 0.26 mmol/l. The impaired left ventricular (LV) function was measured using echocardiography and detecting the ejection fraction (EF). GIK was stopped and a potassium phosphate infusion commenced. As the phosphate and potassium deficiencies were corrected, the neuromuscular and cardiac abnormalities resolved, CKMB fell to normal and LVEF rose from 40% to 72%. We suggest that additional cardiac damage due to hypophosphataemia may have occurred in this patient, who already had cardiac impairment as a result of profound hypokalaemia. Possible mechanisms are discussed.

Original languageEnglish
Pages (from-to)679-681
Number of pages3
JournalPostgraduate Medical Journal
Issue number708
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)


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