Myocardial damage induced by uncontrolled reoxygenation

A. F. Corno, G. Milano, M. Samaja, L. K. Von Segesser

Research output: Contribution to journalArticle

Abstract

To evaluate myocardial impairment induced by uncontrolled reoxygenation, the effects of hypoxia-reoxygenation were compared with ischemia-reperfusion in isolated rat hearts. After stabilization, 2 groups (n = 8) of Langendorff-perfused rat hearts were exposed to 40 minutes of ischemia (10% of baseline flow) or hypoxia (10% of baseline oxygen content) followed by a sudden return to baseline conditions (reperfusion or reoxygenation). The O2 content was identical for the two groups during baseline conditions, O2 shortage, and O2 readmission. Metabolic (lactate production) and functional parameters (heart rate, peak systolic pressure, left ventricular developed pressure, maximal contraction and relaxation rates, end-diastolic pressure, coronary perfusion pressure) were recorded at the end of stabilization, after O2 deficiency, and after 2 minutes of reoxygenation. Systolic function was significantly depressed after ischemia (p <0.0001) but completely recovered to baseline values after 2 minutes of reperfusion. In contrast, systolic function was less severely depressed after hypoxia but failed to return to baseline after 2 minutes of reoxygenation. Diastolic function, unchanged during ischemia-reperfusion, remained significantly impaired during hypoxia-reoxygenation.

Original languageEnglish
Pages (from-to)34-37
Number of pages4
JournalAsian Cardiovascular and Thoracic Annals
Volume8
Issue number1
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Myocardial damage induced by uncontrolled reoxygenation'. Together they form a unique fingerprint.

  • Cite this

    Corno, A. F., Milano, G., Samaja, M., & Von Segesser, L. K. (2000). Myocardial damage induced by uncontrolled reoxygenation. Asian Cardiovascular and Thoracic Annals, 8(1), 34-37.