Myocardial fatty foci in adult patients with tuberous sclerosis complex: Association with gene mutation and multiorgan involvement

Silvia Tresoldi, Alice Munari, Giovanni Di Leo, Giovanni Pompili, Paolo Magistrelli, Francesco Secchi, Francesca La Briola, Maria Paola Canevini, Gianpaolo Cornalba, Francesco Sardanelli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To estimate the association between myocardial fatty foci (MFF) on chest computed tomographic (CT) images and type of gene mutation or multiorgan involvement in patients with tuberous sclerosis complex (TSC). Materials and Methods: This retrospective case-control study was approved by the ethics committee, which waived the need for patient consent. Forty-eight patients with definite TSC (41 women; mean age, 35 years ± 11 [standard deviation]) and 96 age-and sex-matched patients without TSC who had undergone chest CT were evaluated. Two blinded readers independently scored MFF as low-attenuation areas within the myocardium. Patient history, gene mutation, and multiorgan involvement were obtained from clinical records. Cohen k, Mann-Whitney U, χ2 or Fisher exact, Kruskal-Wallis, and Spearman statistics were calculated. Results: One or more MFF was detected in 50% (24 of 48) of patients with TSC; however, no MFF was detected in control patients (P

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalRadiology
Volume277
Issue number2
DOIs
Publication statusPublished - Nov 1 2015

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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