TY - JOUR
T1 - Myocardial fatty foci in adult patients with tuberous sclerosis complex
T2 - Association with gene mutation and multiorgan involvement
AU - Tresoldi, Silvia
AU - Munari, Alice
AU - Di Leo, Giovanni
AU - Pompili, Giovanni
AU - Magistrelli, Paolo
AU - Secchi, Francesco
AU - La Briola, Francesca
AU - Canevini, Maria Paola
AU - Cornalba, Gianpaolo
AU - Sardanelli, Francesco
PY - 2015/11/1
Y1 - 2015/11/1
N2 - Purpose: To estimate the association between myocardial fatty foci (MFF) on chest computed tomographic (CT) images and type of gene mutation or multiorgan involvement in patients with tuberous sclerosis complex (TSC). Materials and Methods: This retrospective case-control study was approved by the ethics committee, which waived the need for patient consent. Forty-eight patients with definite TSC (41 women; mean age, 35 years ± 11 [standard deviation]) and 96 age-and sex-matched patients without TSC who had undergone chest CT were evaluated. Two blinded readers independently scored MFF as low-attenuation areas within the myocardium. Patient history, gene mutation, and multiorgan involvement were obtained from clinical records. Cohen k, Mann-Whitney U, χ2 or Fisher exact, Kruskal-Wallis, and Spearman statistics were calculated. Results: One or more MFF was detected in 50% (24 of 48) of patients with TSC; however, no MFF was detected in control patients (P
AB - Purpose: To estimate the association between myocardial fatty foci (MFF) on chest computed tomographic (CT) images and type of gene mutation or multiorgan involvement in patients with tuberous sclerosis complex (TSC). Materials and Methods: This retrospective case-control study was approved by the ethics committee, which waived the need for patient consent. Forty-eight patients with definite TSC (41 women; mean age, 35 years ± 11 [standard deviation]) and 96 age-and sex-matched patients without TSC who had undergone chest CT were evaluated. Two blinded readers independently scored MFF as low-attenuation areas within the myocardium. Patient history, gene mutation, and multiorgan involvement were obtained from clinical records. Cohen k, Mann-Whitney U, χ2 or Fisher exact, Kruskal-Wallis, and Spearman statistics were calculated. Results: One or more MFF was detected in 50% (24 of 48) of patients with TSC; however, no MFF was detected in control patients (P
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U2 - 10.1148/radiol.2015141890
DO - 10.1148/radiol.2015141890
M3 - Article
C2 - 26069922
AN - SCOPUS:84946085076
VL - 277
SP - 398
EP - 405
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -