Myocardial hibernation vs repetitive stunning in patients

P. G. Camici, O. Rimoldi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Myocardial hibernation is a state of persistently impaired left ventricular function in patients with coronary artery disease that was thought to be caused by a chronic reduction in resting myocardial blood flow in a segment subtended by a diseased coronary artery. However, recent studies using positron emission tomography have demonstrated that absolute myocardial blood flow (ml/min/g) to hibernating myocardium is within normal limits in most patients. If resting flow is not reduced, one must therefore suspect an alternative 'trigger' for hibernation that is still a consequence of coronary artery disease and ischemia. We suspect that hibernating myocardium may be the result of repetitive myocardial stunning. Myocardial stunning is the reversible contractile dysfunction occurring after a period of myocardial ischemia that persists for a period of time despite the return of blood flow to normal. Myocardial stunning has been demonstrated in humans in the setting of thrombolysis, coronary angioplasty, coronary artery bypass surgery, and coronary artery spasm. Furthermore, stunning has been demonstrated after exercise in patients with coronary artery disease, and recent studies have provided evidence that repetitive episodes of exercise-induced ischemia can lead to cumulative and prolonged left ventricular dysfunction.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalCardiology in Review
Volume7
Issue number1
Publication statusPublished - 1999

Fingerprint

Myocardial Stunning
Coronary Artery Disease
Myocardium
Ischemia
Exercise
Hibernation
Spasm
Left Ventricular Dysfunction
Angioplasty
Left Ventricular Function
Coronary Artery Bypass
Positron-Emission Tomography
Myocardial Ischemia
Coronary Vessels

Keywords

  • Coronary artery disease
  • Coronary revascularization
  • Left ventricular function
  • Myocardial blood flow
  • Myocardial viability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Myocardial hibernation vs repetitive stunning in patients. / Camici, P. G.; Rimoldi, O.

In: Cardiology in Review, Vol. 7, No. 1, 1999, p. 39-43.

Research output: Contribution to journalArticle

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