Abstract
Statin pretreatment has been reported to have a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We prospectively evaluated the effect of long-term statin therapy on infarct size (IS), myocardial salvage index (MSI), and microvascular obstruction (MVO) in consecutive patients with STEMI who underwent primary PCI. Two-hundred thirty patients with STEMI (mean age 61 ± 11 years, 183 men) who underwent primary PCI were evaluated with cardiac magnetic resonance (CMR) imaging during hospitalization (median 4 days after primary PCI). In all patients, we measured peak troponin I level, whereas IS, MSI, and MVO were determined by CMR. Fifty patients (22%) were on long-term statin therapy and showed a significantly lower troponin I peak value compared to patients without previous statins (54 ± 47 vs 88 ± 106 ng/ml; p = 0.02). At CMR evaluation, IS related to the index event was significantly smaller (12.5 ± 11.5 vs 18.5 ± 18.5 g, p = 0.05), and MSI was higher (0.68 ± 0.25 vs 0.52 ± 0.30; p
| Original language | English |
|---|---|
| Pages (from-to) | 1791-1797 |
| Number of pages | 7 |
| Journal | The American Journal of Cardiology |
| Volume | 116 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 15 2015 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Myocardial Infarct Size in Patients on Long-Term Statin Therapy Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. / Marenzi, Giancarlo; Cosentino, Nicola; Cortinovis, Sarah; Milazzo, Valentina; Rubino, Mara; Cabiati, Angelo; De Metrio, Monica; Moltrasio, Marco; Lauri, Gianfranco; Campodonico, Jeness; Pontone, Gianluca; Andreini, Daniele; Bonomi, Alice; Veglia, Fabrizio; Bartorelli, Antonio.
In: The American Journal of Cardiology, Vol. 116, No. 12, 15.12.2015, p. 1791-1797.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myocardial Infarct Size in Patients on Long-Term Statin Therapy Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction
AU - Marenzi, Giancarlo
AU - Cosentino, Nicola
AU - Cortinovis, Sarah
AU - Milazzo, Valentina
AU - Rubino, Mara
AU - Cabiati, Angelo
AU - De Metrio, Monica
AU - Moltrasio, Marco
AU - Lauri, Gianfranco
AU - Campodonico, Jeness
AU - Pontone, Gianluca
AU - Andreini, Daniele
AU - Bonomi, Alice
AU - Veglia, Fabrizio
AU - Bartorelli, Antonio
PY - 2015/12/15
Y1 - 2015/12/15
N2 - Statin pretreatment has been reported to have a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We prospectively evaluated the effect of long-term statin therapy on infarct size (IS), myocardial salvage index (MSI), and microvascular obstruction (MVO) in consecutive patients with STEMI who underwent primary PCI. Two-hundred thirty patients with STEMI (mean age 61 ± 11 years, 183 men) who underwent primary PCI were evaluated with cardiac magnetic resonance (CMR) imaging during hospitalization (median 4 days after primary PCI). In all patients, we measured peak troponin I level, whereas IS, MSI, and MVO were determined by CMR. Fifty patients (22%) were on long-term statin therapy and showed a significantly lower troponin I peak value compared to patients without previous statins (54 ± 47 vs 88 ± 106 ng/ml; p = 0.02). At CMR evaluation, IS related to the index event was significantly smaller (12.5 ± 11.5 vs 18.5 ± 18.5 g, p = 0.05), and MSI was higher (0.68 ± 0.25 vs 0.52 ± 0.30; p
AB - Statin pretreatment has been reported to have a cardioprotective effect in patients undergoing elective or urgent percutaneous coronary intervention (PCI). However, data on patients with ST-elevation myocardial infarction (STEMI) undergoing primary PCI are still controversial. We prospectively evaluated the effect of long-term statin therapy on infarct size (IS), myocardial salvage index (MSI), and microvascular obstruction (MVO) in consecutive patients with STEMI who underwent primary PCI. Two-hundred thirty patients with STEMI (mean age 61 ± 11 years, 183 men) who underwent primary PCI were evaluated with cardiac magnetic resonance (CMR) imaging during hospitalization (median 4 days after primary PCI). In all patients, we measured peak troponin I level, whereas IS, MSI, and MVO were determined by CMR. Fifty patients (22%) were on long-term statin therapy and showed a significantly lower troponin I peak value compared to patients without previous statins (54 ± 47 vs 88 ± 106 ng/ml; p = 0.02). At CMR evaluation, IS related to the index event was significantly smaller (12.5 ± 11.5 vs 18.5 ± 18.5 g, p = 0.05), and MSI was higher (0.68 ± 0.25 vs 0.52 ± 0.30; p
UR - http://www.scopus.com/inward/record.url?scp=84952872841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84952872841&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2015.09.016
DO - 10.1016/j.amjcard.2015.09.016
M3 - Article
VL - 116
SP - 1791
EP - 1797
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12
ER -