Myocardial infarction and histamine release

F. Zaca, M. S. Benassi, M. Ghinelli, M. Trianni, R. Vaccarino, E. Malavolta, M. Muratori, S. Lenzi

Research output: Contribution to journalArticlepeer-review


On the basis of previous data suggesting the involvement of cardiac histamine in ischemic heart disease (IHD), we evaluated plasma histamine (H) and creatine-kinase isoenzyme (CK-MB) level in cardiac and healthy subjects. 20 patients with acute myocardial infarction (AMI) (10 developing AMI in Hospital, thus making possible the detection of plasma H level before acute event), 10 patients with IHD not developing AMI and 10 presumably healthy subjects were admitted to the study. 15 of all patients with AMI showed a correlated H and CK-MB trend during AMI reaching the highest peak 24 hours after onset of pain. 7 of the patients with IHD who developed AMI in Hospital showed a slightly higher plasma H level, before AMI, than those with IHD who did not develop AMI. A possible role of histamine in the pathogenesis of AMI is discussed.

Original languageEnglish
Pages (from-to)258-261
Number of pages4
JournalAgents and Actions
Issue number1-2
Publication statusPublished - Apr 1986

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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