Ischemia miocardica da sforzo. Correlazioni tra livelli ematici di trombossano B2 e variazioni di flusso e resistenze coronariche.

Translated title of the contribution: Myocardial ischemia during exertion. Correlations between blood levels of thromboxane B2 and changes in coronary flow and resistance

S. De Servi, E. Vidale, A. Mussini, A. Cafiso, A. Gavazzi, C. Falcone, E. Bramucci, L. Angoli, M. Ferrario, S. Ghio

Research output: Contribution to journalArticle

Abstract

Platelet activation, with the subsequent generation of Thromboxane (Tx) A2, has been implied as a possible cause of resting as well as exercise induced myocardial ischemia. To verify the latter hypothesis, we measured the exercise release of TxB2, the stable metabolite of TxA2, in 9 patients with exertional angina and left anterior descending coronary artery disease. Three of the patients also suffered from angina at rest, due to coronary vasospasm. The great cardiac vein flow, venous efflux from the myocardial territory supplied by the left anterior descending, was determined by the thermodilution technique in the basal conditions, at peak exercise when angina and/or significant ST changes occurred, and 20 min after exercise. Simultaneous blood samples were drawn from the great cardiac vein and a peripheral artery for TxB2 measurements. Regional coronary resistances were calculated as the ratio of mean arterial pressure and coronary flow. At peak exercise the great cardiac vein flow increased and regional coronary resistances decreased in all patients, except in one who showed exercise induced coronary spasm. An increase in TxB2 release was found in 3 patients, a decrease in 3, while the remaining 3 patients did not show significant changes. After exercise the great cardiac vein flow and regional coronary resistances returned to control values in all, whereas both great cardiac vein and arterial TxB2 levels were increased in 6 patients. Our data show that no apparent relation exists between exercise-induced changes in coronary resistances and generation of TxB2.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageItalian
Pages (from-to)5-9
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume15
Issue number1
Publication statusPublished - Jan 1985

Fingerprint

Thromboxane B2
Myocardial Ischemia
Exercise
Veins
Coronary Vasospasm
Thermodilution
Thromboxane A2
Unstable Angina
Platelet Activation
Spasm
Coronary Artery Disease
Arterial Pressure
Arteries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ischemia miocardica da sforzo. Correlazioni tra livelli ematici di trombossano B2 e variazioni di flusso e resistenze coronariche. / De Servi, S.; Vidale, E.; Mussini, A.; Cafiso, A.; Gavazzi, A.; Falcone, C.; Bramucci, E.; Angoli, L.; Ferrario, M.; Ghio, S.

In: Giornale Italiano di Cardiologia, Vol. 15, No. 1, 01.1985, p. 5-9.

Research output: Contribution to journalArticle

De Servi, S. ; Vidale, E. ; Mussini, A. ; Cafiso, A. ; Gavazzi, A. ; Falcone, C. ; Bramucci, E. ; Angoli, L. ; Ferrario, M. ; Ghio, S. / Ischemia miocardica da sforzo. Correlazioni tra livelli ematici di trombossano B2 e variazioni di flusso e resistenze coronariche. In: Giornale Italiano di Cardiologia. 1985 ; Vol. 15, No. 1. pp. 5-9.
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abstract = "Platelet activation, with the subsequent generation of Thromboxane (Tx) A2, has been implied as a possible cause of resting as well as exercise induced myocardial ischemia. To verify the latter hypothesis, we measured the exercise release of TxB2, the stable metabolite of TxA2, in 9 patients with exertional angina and left anterior descending coronary artery disease. Three of the patients also suffered from angina at rest, due to coronary vasospasm. The great cardiac vein flow, venous efflux from the myocardial territory supplied by the left anterior descending, was determined by the thermodilution technique in the basal conditions, at peak exercise when angina and/or significant ST changes occurred, and 20 min after exercise. Simultaneous blood samples were drawn from the great cardiac vein and a peripheral artery for TxB2 measurements. Regional coronary resistances were calculated as the ratio of mean arterial pressure and coronary flow. At peak exercise the great cardiac vein flow increased and regional coronary resistances decreased in all patients, except in one who showed exercise induced coronary spasm. An increase in TxB2 release was found in 3 patients, a decrease in 3, while the remaining 3 patients did not show significant changes. After exercise the great cardiac vein flow and regional coronary resistances returned to control values in all, whereas both great cardiac vein and arterial TxB2 levels were increased in 6 patients. Our data show that no apparent relation exists between exercise-induced changes in coronary resistances and generation of TxB2.(ABSTRACT TRUNCATED AT 250 WORDS)",
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