Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi; Carlo Pellegrini; Marco Maurelli; Mirko Belliato; Fabio Sciutti; Andrea Bottazzi; Paola Alessandra Sepe; Tullia Resasco; Rita Camporotondo; Raffaele Bruno; Fausto Baldanti; Stefania Paolucci; Stefano Pelenghi; Giorgio Antonio Iotti; Francesco Mojoli; Eloisa Arbustini

doi:10.1002/ejhf.1828

Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi, Carlo Pellegrini, Marco Maurelli, Mirko Belliato, Fabio Sciutti, Andrea Bottazzi, Paola Alessandra Sepe, Tullia Resasco, Rita Camporotondo, Raffaele Bruno, Fausto Baldanti, Stefania Paolucci, Stefano Pelenghi, Giorgio Antonio Iotti, Francesco Mojoli, Eloisa Arbustini

Research output: Contribution to journal › Article › peer-review

Abstract

We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

Original language	English
Journal	European Journal of Heart Failure
DOIs	https://doi.org/10.1002/ejhf.1828
Publication status	Accepted/In press - Jan 1 2020

Keywords

Cardiac injury
Cardiogenic shock
Coronavirus
Extracorporeal membrane oxygenation
Myocardial inflammation
SARS-CoV-2

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1002/ejhf.1828

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Tavazzi, G., Pellegrini, C., Maurelli, M., Belliato, M., Sciutti, F., Bottazzi, A., Sepe, P. A., Resasco, T., Camporotondo, R., Bruno, R., Baldanti, F., Paolucci, S., Pelenghi, S., Iotti, G. A., Mojoli, F., & Arbustini, E. (Accepted/In press). Myocardial localization of coronavirus in COVID-19 cardiogenic shock. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1828

Myocardial localization of coronavirus in COVID-19 cardiogenic shock. / Tavazzi, Guido ; Pellegrini, Carlo; Maurelli, Marco; Belliato, Mirko ; Sciutti, Fabio ; Bottazzi, Andrea; Sepe, Paola Alessandra; Resasco, Tullia; Camporotondo, Rita ; Bruno, Raffaele ; Baldanti, Fausto ; Paolucci, Stefania ; Pelenghi, Stefano; Iotti, Giorgio Antonio; Mojoli, Francesco ; Arbustini, Eloisa.

In: European Journal of Heart Failure, 01.01.2020.

Research output: Contribution to journal › Article › peer-review

Tavazzi, Guido ; Pellegrini, Carlo ; Maurelli, Marco ; Belliato, Mirko ; Sciutti, Fabio ; Bottazzi, Andrea ; Sepe, Paola Alessandra ; Resasco, Tullia ; Camporotondo, Rita ; Bruno, Raffaele ; Baldanti, Fausto ; Paolucci, Stefania ; Pelenghi, Stefano ; Iotti, Giorgio Antonio ; Mojoli, Francesco ; Arbustini, Eloisa. / Myocardial localization of coronavirus in COVID-19 cardiogenic shock. In: European Journal of Heart Failure. 2020.

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Myocardial localization of coronavirus in COVID-19 cardiogenic shock

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