Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi; Carlo Pellegrini; Marco Maurelli; Mirko Belliato; Fabio Sciutti; Andrea Bottazzi; Paola Alessandra Sepe; Tullia Resasco; Rita Camporotondo; Raffaele Bruno; Fausto Baldanti; Stefania Paolucci; Stefano Pelenghi; Giorgio Antonio Iotti; Francesco Mojoli; Eloisa Arbustini

doi:10.1002/ejhf.1828

Myocardial localization of coronavirus in COVID-19 cardiogenic shock

Guido Tavazzi, Carlo Pellegrini, Marco Maurelli, Mirko Belliato, Fabio Sciutti, Andrea Bottazzi, Paola Alessandra Sepe, Tullia Resasco, Rita Camporotondo, Raffaele Bruno, Fausto Baldanti, Stefania Paolucci, Stefano Pelenghi, Giorgio Antonio Iotti, Francesco Mojoli, Eloisa Arbustini

Research output: Contribution to journal › Article

Abstract

We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

Original language	English
Journal	European Journal of Heart Failure
DOIs	https://doi.org/10.1002/ejhf.1828
Publication status	Accepted/In press - Jan 1 2020

Keywords

Cardiac injury
Cardiogenic shock
Coronavirus
Extracorporeal membrane oxygenation
Myocardial inflammation
SARS-CoV-2

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.1002/ejhf.1828

Fingerprint Dive into the research topics of 'Myocardial localization of coronavirus in COVID-19 cardiogenic shock'. Together they form a unique fingerprint.

Cite this

Tavazzi, G., Pellegrini, C., Maurelli, M., Belliato, M., Sciutti, F., Bottazzi, A., Sepe, P. A., Resasco, T., Camporotondo, R., Bruno, R., Baldanti, F., Paolucci, S., Pelenghi, S., Iotti, G. A., Mojoli, F., & Arbustini, E. (Accepted/In press). Myocardial localization of coronavirus in COVID-19 cardiogenic shock. European Journal of Heart Failure. https://doi.org/10.1002/ejhf.1828

Myocardial localization of coronavirus in COVID-19 cardiogenic shock. / Tavazzi, Guido ; Pellegrini, Carlo ; Maurelli, Marco ; Belliato, Mirko ; Sciutti, Fabio ; Bottazzi, Andrea; Sepe, Paola Alessandra; Resasco, Tullia; Camporotondo, Rita ; Bruno, Raffaele ; Baldanti, Fausto ; Paolucci, Stefania ; Pelenghi, Stefano ; Iotti, Giorgio Antonio ; Mojoli, Francesco ; Arbustini, Eloisa.

In: European Journal of Heart Failure, 01.01.2020.

Research output: Contribution to journal › Article

Tavazzi, Guido ; Pellegrini, Carlo ; Maurelli, Marco ; Belliato, Mirko ; Sciutti, Fabio ; Bottazzi, Andrea ; Sepe, Paola Alessandra ; Resasco, Tullia ; Camporotondo, Rita ; Bruno, Raffaele ; Baldanti, Fausto ; Paolucci, Stefania ; Pelenghi, Stefano ; Iotti, Giorgio Antonio ; Mojoli, Francesco ; Arbustini, Eloisa. / Myocardial localization of coronavirus in COVID-19 cardiogenic shock. In: European Journal of Heart Failure. 2020.

@article{648771064585484f9f87e0634d9414ca,

title = "Myocardial localization of coronavirus in COVID-19 cardiogenic shock",

abstract = "We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.",

keywords = "Cardiac injury, Cardiogenic shock, Coronavirus, Extracorporeal membrane oxygenation, Myocardial inflammation, SARS-CoV-2",

author = "Guido Tavazzi and Carlo Pellegrini and Marco Maurelli and Mirko Belliato and Fabio Sciutti and Andrea Bottazzi and Sepe, {Paola Alessandra} and Tullia Resasco and Rita Camporotondo and Raffaele Bruno and Fausto Baldanti and Stefania Paolucci and Stefano Pelenghi and Iotti, {Giorgio Antonio} and Francesco Mojoli and Eloisa Arbustini",

year = "2020",

month = jan,

day = "1",

doi = "10.1002/ejhf.1828",

language = "English",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "John Wiley & Sons, Ltd",

}

TY - JOUR

T1 - Myocardial localization of coronavirus in COVID-19 cardiogenic shock

AU - Tavazzi, Guido

AU - Pellegrini, Carlo

AU - Maurelli, Marco

AU - Belliato, Mirko

AU - Sciutti, Fabio

AU - Bottazzi, Andrea

AU - Sepe, Paola Alessandra

AU - Resasco, Tullia

AU - Camporotondo, Rita

AU - Bruno, Raffaele

AU - Baldanti, Fausto

AU - Paolucci, Stefania

AU - Pelenghi, Stefano

AU - Iotti, Giorgio Antonio

AU - Mojoli, Francesco

AU - Arbustini, Eloisa

PY - 2020/1/1

Y1 - 2020/1/1

N2 - We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

AB - We describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus (SARS-CoV-2) in a 69-year-old patient with flu-like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous-arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low-grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

KW - Cardiac injury

KW - Cardiogenic shock

KW - Coronavirus

KW - Extracorporeal membrane oxygenation

KW - Myocardial inflammation

KW - SARS-CoV-2

UR - http://www.scopus.com/inward/record.url?scp=85083865650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85083865650&partnerID=8YFLogxK

U2 - 10.1002/ejhf.1828

DO - 10.1002/ejhf.1828

M3 - Article

C2 - 32275347

AN - SCOPUS:85083865650

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1388-9842

ER -