Proliferazione mitocondriale miocardica e aritmie in un ciclista: ruolo dell’uso di eritropoietina

Translated title of the contribution: Myocardial mitochondrial proliferation and arrhythmias in a cyclist: The role of erythropoietin

Massimiliano Bianco, Vincenzo Palmieri, Salvatore F. Gervasi, Francesco Cuccaro, Sebastiano Orvieto, Antonio Dello Russo, Carla Giordano, Paolo Zeppilli, Giulia D’Amati

Research output: Contribution to journalArticlepeer-review

Abstract

Ventricular arrhythmias (VAs) in competitive athletes are a challenging problem. They may be linked to structural or functional cardiomyopathies, but the role of banned drugs utilization must always be considered. We report the case of a young asymptomatic professional cyclist with frequent and repetitive VAs, an apparently normal heart at imaging and history of erythropoietin (EPO) use. At the electroanatomical mapping during the electrophysiological study, a low-voltage area in the right ventricular outflow tract was documented. At biopsy, we unexpectedly found mitochondrial proliferation into myocardiocytes. As mitochondrial myopathies/cardiomyopathies were ruled out, we considered the possibility of a link between EPO assumption and this mitochondrial proliferation. In this case, moreover, the artificial and inappropriate stimulus for mitochondrial proliferation induced by EPO has the potential to explain the new occurrence of VAs.

Translated title of the contributionMyocardial mitochondrial proliferation and arrhythmias in a cyclist: The role of erythropoietin
Original languageItalian
Pages (from-to)453-459
Number of pages7
JournalMedicina dello Sport
Volume72
Issue number3
DOIs
Publication statusPublished - 2019

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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