TY - JOUR
T1 - Myocardial perfusion defects after radiation therapy and anthracycline chemotherapy for left breast cancer
T2 - A possible marker of microvascular damage. Three cases and review of the literature
AU - Gallucci, Giuseppina
AU - Capobianco, Alba Maria
AU - Coccaro, Mariarosa
AU - Venetucci, Angela
AU - Suriano, Vincenzo
AU - Fusco, Vincenzo
PY - 2008/1
Y1 - 2008/1
N2 - Radiation therapy to the thorax may induce early and late cardiac adverse effects if large parts of the heart have been included in the irradiation field and particularly if anthracycline-containing chemotherapy is concomitantly administered. We describe 3 cases of cardiotoxicity in patients with left breast cancer treated with anthracycline-containing chemotherapy and left thoracic radiotherapy. In 2 cases we observed asymptomatic electrocardiographic abnormalities of ventricular repolarization mimicking anterior myocardial ischemia and SPECT reversible myocardial perfusion defects. In 1 case we observed echocardiographic abnormalities of left ventricular wall motion and reversible myocardial perfusion abnormalities. We recommend close cardiac monitoring of patients treated with anthracycline chemotherapy and left thoracic radiotherapy to better understand the clinical impact of these abnormalities.
AB - Radiation therapy to the thorax may induce early and late cardiac adverse effects if large parts of the heart have been included in the irradiation field and particularly if anthracycline-containing chemotherapy is concomitantly administered. We describe 3 cases of cardiotoxicity in patients with left breast cancer treated with anthracycline-containing chemotherapy and left thoracic radiotherapy. In 2 cases we observed asymptomatic electrocardiographic abnormalities of ventricular repolarization mimicking anterior myocardial ischemia and SPECT reversible myocardial perfusion defects. In 1 case we observed echocardiographic abnormalities of left ventricular wall motion and reversible myocardial perfusion abnormalities. We recommend close cardiac monitoring of patients treated with anthracycline chemotherapy and left thoracic radiotherapy to better understand the clinical impact of these abnormalities.
KW - Anthracycline therapy
KW - Breast cancer
KW - Cardiotoxicity
KW - Myocardial perfusion defects
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=41749083458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=41749083458&partnerID=8YFLogxK
M3 - Article
C2 - 18468349
AN - SCOPUS:41749083458
VL - 94
SP - 129
EP - 133
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 1
ER -