Abstract
The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.
Translated title of the contribution | Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis |
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Original language | Italian |
Pages (from-to) | 591-593 |
Number of pages | 3 |
Journal | Cardiologia |
Volume | 37 |
Issue number | 8 |
Publication status | Published - Aug 1992 |
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine