Abstract
The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.
| Original language | Italian |
|---|---|
| Pages (from-to) | 591-593 |
| Number of pages | 3 |
| Journal | Cardiologia |
| Volume | 37 |
| Issue number | 8 |
| Publication status | Published - Aug 1992 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+. / Gambassi, G.; Capogrossi, M. C.; Mugelli, A.; Carbonin, P.
In: Cardiologia, Vol. 37, No. 8, 08.1992, p. 591-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+.
AU - Gambassi, G.
AU - Capogrossi, M. C.
AU - Mugelli, A.
AU - Carbonin, P.
PY - 1992/8
Y1 - 1992/8
N2 - The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.
AB - The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=0026907106&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026907106&partnerID=8YFLogxK
M3 - Articolo
C2 - 1486582
AN - SCOPUS:0026907106
VL - 37
SP - 591
EP - 593
JO - Cardiologia (Rome, Italy)
JF - Cardiologia (Rome, Italy)
SN - 0393-1978
IS - 8
ER -