La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+.

Translated title of the contribution: Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis

G. Gambassi, M. C. Capogrossi, A. Mugelli, P. Carbonin

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.

Translated title of the contributionMyocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis
Original languageItalian
Pages (from-to)591-593
Number of pages3
JournalCardiologia
Volume37
Issue number8
Publication statusPublished - Aug 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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