La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+.

G. Gambassi; M. C. Capogrossi; A. Mugelli; P. Carbonin

La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+.

Translated title of the contribution: Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis

G. Gambassi, M. C. Capogrossi, A. Mugelli, P. Carbonin

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.

Translated title of the contribution	Myocardial protection in hypothermia depends on the modulation of intracellular Ca2+ homeostasis
Original language	Italian
Pages (from-to)	591-593
Number of pages	3
Journal	Cardiologia
Volume	37
Issue number	8
Publication status	Published - Aug 1992

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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abstract = "The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.",

author = "G. Gambassi and Capogrossi, {M. C.} and A. Mugelli and P. Carbonin",

year = "1992",

month = aug,

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AU - Gambassi, G.

AU - Capogrossi, M. C.

AU - Mugelli, A.

AU - Carbonin, P.

PY - 1992/8

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N2 - The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.

AB - The effect of a mild hypothermia (30 degrees C) on sarcoplasmic reticulum (SR) Ca2+ content and release has been evaluated in single cardiac cells loaded with the fluorescent indicator, indo-1. SR Ca2+ content, assessed by rapid caffeine application, is more pronounced at 30 than at 37 degrees C. However, hypothermia reduces the occurrence of spontaneous SR Ca2+ oscillations. In fact, following electrical stimulation, the time to onset of first SR Ca2+ oscillation was increased and their frequency reduced. Since spontaneous SR Ca2+ releases are implicated on the genesis of certain forms of ventricular arrhythmias, the protection provided by a mild hypothermia may be dependent on the modulation of intracellular Ca2+ homeostasis.

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JF - Cardiologia (Rome, Italy)

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La protezione miocardica in ipotermia dipende dalla modulazione della omeostasi intracellulare del Ca2+.

Abstract

ASJC Scopus subject areas

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